NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

InaD-like protein - Mus musculus - NucEnvDB

InaD-like protein (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	InaD-like protein
Accession Code	Q63ZW7
Gene	Patj
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1834)
MPENPAAEKMQVLQVLDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRKGLLVFTDGSITNGNAQRPCSNVTASELLPWTQKSASEDFNSVIQQMAQGR HVEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGSVADRDHRLKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVAREVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGF GIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPVGEIAVTPPTPVSLPVALPAVATRTLDSDRSPFETYSVELVKKDGQSLGIRIVGYVGTAHPG EASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEHSSSRETVAEPPKVPERAGSPKPEANLSVEAEEIGERLDNLKNNTVQALEKPDVYPEK VPGSPENELKSRWENLLGPDYEVMVATLDAQIADDEELQKYSKLLPIHTLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDE PRTMEPALLEAEVDHSVDVNIEDDDDGELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEDEK EERFSLHSNNNGDSSEPADAVHEIHSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDVDSSSEAWEMHEFLSPPLDGRGEEREMLVDEEYELYQDHLRAMESNPPPPHIREAAPASPVLELQAG TQWLHANLSGGERLECHDAESMMSAYPQEMQQYSYSTADMMEETFGLDSRAPIPSSEGNGQHGRFDDMGHLHSLTSSSLDLGMMIPSDLQGPGVLVDLPAVAQRREQEDLPLYRLPSARVVTKPSSHMGL VSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHAEAVEAIKSAGNPVVFVVQSLSSTPR VIPTVNNKGKTPAPNQDQNTQERKAKRHGTAPPPMKLPPPYRAPSADMEGSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI LYGRSHQNASAIIKTAPTRVKLVFIRNEDAVSQMAVAPFPELSHSPSPVEDLGGTELVSSEEESSVDAKHLPEPESSKPEDLSQVVDDNMVAEQQKESESPDSAACQIKQQTYSTQVSSSSQDSPSSPAP LCQSAHADVTGSGNFQAPLPVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVVYRDEAQYRD EENLEVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQILSVNGEDMRHASQETVATILKCVQGLVQLEIGRLRAGSWAASRKTSQNSQGDQHSAHSSCRPSFAPVITSLQNLV GTKRSSDPPQKCTEEEPRTVEIIRELSDALGISIAGGKGSPLGDIPIFIAMIQANGVAARTQKLKVGDRIVSINGQPLDGLSHTDAVNLLKNAFGRIILQVVADTNISAIATQLEIMSAGSQLGSPTADR HPEDTEEQMQRTAD

Subcellular Location

Description
Cell junction, tight junction {By SimilarityUniProtKB:Q8NI35}. Apical cell membrane {By SimilarityUniProtKB:Q8NI35}; Peripheral membrane protein {By SimilarityUniProtKB:Q8NI35}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:14988405}. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (By similarity). Localized in the paranodal region of myelinating Schwann cells (PubMed:12403818). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250\|UniProtKB:E2QYC9, By SimilarityUniProtKB:Q8NI35, ECO:0000269\|PubMed:12403818}. [Isoform 3]: Cytoplasm. Cytoplasm, perinuclear region. Note=Concentrates around the nucleus upon HTR2A coexpression.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q8NI35}
Assigned Ontology terms

Cellular Component	Apical Part Of Cell (GO:0045177) Apical Plasma Membrane (GO:0016324) Bicellular Tight Junction (GO:0005923) Cell Junction (GO:0030054) Centriolar Satellite (GO:0034451) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) Protein-Containing Complex (GO:0032991) Subapical Complex (GO:0035003) Tight Junction (GO:0070160)

Biology & Function

Description
Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11872753). Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (PubMed:11872753). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). {By SimilarityUniProtKB:E2QYC9, By SimilarityUniProtKB:Q8NI35, Experimental EvidencePubMed:11872753}.
Assigned Ontology terms

Biological Process	Establishment Of Apical/Basal Cell Polarity (GO:0035089) Tight Junction Assembly (GO:0120192)
Molecular Function

Protein-Protein Interactions

Interactions with other proteins (14 interactors)

Partner (UniProt)		IntAct	Confidence score
O35240	Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC)	EBI-8158519	0.51
P49655	ATP-sensitive inward rectifier potassium channel 10 (ATP-sensitive inward rectifier potassium channel KAB-2) (BIR10) (Brain-specific inwardly rectifying K(+) channel 1) (BIRK1) (Inward rectifier K(+) channel Kir4.1) (Potassium channel, inwardly rectifying subfamily J member 10)	EBI-8689438	0.37
P35436	Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)	EBI-8689421	0.51
Q62645	Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)	EBI-8689537	0.51
Q00960	Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)	EBI-8689473	0.51
Q62644	Glutamate receptor	EBI-8689517	0.37
Q99712	ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)	EBI-8689848	0.51
Q00961	Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)	EBI-8690026	0.51
Q62888	Neuroligin-2	EBI-8690119	0.37
Q63376	Neurexin-2-beta (Neurexin II-beta)	EBI-8690093	0.37
Q9JM63	ATP-sensitive inward rectifier potassium channel 10 (Inward rectifier K(+) channel Kir4.1) (Potassium channel, inwardly rectifying subfamily J member 10)	EBI-8689922	0.40
O88932	ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)	EBI-8689908	0.40
Q60857	Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)	EBI-15633398	0.35
Q61327	Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)	EBI-15633420	0.35

Cross-References

Database	Links
UNIPROT	Q63ZW7 A2ADS7 O70471 Q5PRG3 Q6P6J1 Q80YR8 Q8BPB9
Pfam	PF09045 PF00595
PROSITE	PS51022 PS50106

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