Nucleus inner membrane {Experimental EvidencePubMed:16339967, Experimental EvidencePubMed:17062158}; Multi-pass membrane protein {Experimental EvidencePubMed:16339967}. Nucleus envelope {ECO:0000250|UniProtKB:Q8NC56}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NC56}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (By similarity). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (By similarity). Recruited to the reforming NE on chromatin disks in early anaphase (By similarity). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (By similarity). {ECO:0000250|UniProtKB:Q8NC56, Experimental EvidencePubMed:16339967}.
The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The inner membrane of the nucleus is the membrane which separates the nuclear matrix from the intermembrane space. In mammals, the inner nuclear membrane is associated with heterochromatin and the nuclear lamina.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear structure integrity and nuclear envelope reformation after mitosis (PubMed:16339967). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated nuclear envelope reformation (By similarity). Promotes ESCRT-mediated nuclear envelope closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity). Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465). Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741). {By
SimilarityUniProtKB:Q8NC56, Experimental EvidencePubMed:16339967, Experimental EvidencePubMed:17062158, Experimental EvidencePubMed:19720741, Experimental EvidencePubMed:25790465}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory