NucEnvDB
NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Twinfilin-2 - Danio rerio - NucEnvDB
Twinfilin-2 (
Danio rerio
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Cross-References
General Information
Protein Information
Protein Name
Twinfilin-2
Accession Code
Q6GMH3
Gene
twf2
Organism
Danio rerio
| Zebrafish (Taxonomy:
7955
)
Part of Reference Proteome?
Yes
Sequence (Length: 347)
Show
MFLVLVVTEELREFLARARNGTGRLIQVLIRDEQLVLGAYREPRHSWDKDYDPVLLPLLDPLEPCYILYRLDSKNAQGYEWLFISWSPDQSPVRQKMLYAATRATVKKEFGGGHVKDEMFGTVEEDICLQ
GYLRHITSCSAPAPLTVAEQELQRIKITEVKAEISVDPKHQTLQGLAFPLQAEAKRALKQLAERRINYIQLKLDTEKETIDLVHTSPTDIRDLPCRIPLDTPRYHFFLYKHSHEGDYLESVVFIYSMPGY
SCSIKERMLYSSCKSRLLDEVERDFHLEVAKKLEIDSGEELTEEYLYDEVHPKQHAHKQAFAKPRGPAGKRGNKRLIKGGGENGGNS
Subcellular Location
Description
Show
Cytoplasm, cytoskeleton {
By Similarity
}. Cytoplasm, perinuclear region {
By Similarity
}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. {
By Similarity
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
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Cellular Component
Actin Filament
(
GO:0005884
)
Cytoplasm
(
GO:0005737
)
Myofibril
(
GO:0030016
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
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Biology & Function
Description
Hide
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). {
By Similarity
}.
Assigned Ontology terms
Show
Biological Process
Actin Filament Depolymerization
(
GO:0030042
)
Barbed-End Actin Filament Capping
(
GO:0051016
)
Positive Regulation Of Neuron Projection Development
(
GO:0010976
)
Regulation Of Lamellipodium Assembly
(
GO:0010591
)
Sequestering Of Actin Monomers
(
GO:0042989
)
Molecular Function
Actin Filament Binding
(
GO:0051015
)
Actin Monomer Binding
(
GO:0003785
)
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Cross-References
Database
Links
UNIPROT
Q6GMH3
Pfam
PF00241
PROSITE
PS51263
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory