NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Solute carrier family 2, facilitated glucose transporter member 12 - Danio rerio - NucEnvDB

Solute carrier family 2, facilitated glucose transporter member 12 (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Solute carrier family 2, facilitated glucose transporter member 12
Accession Code	Q6NWF1
Gene	slc2a12
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 610)
MDAPEESIRMTSDPQSKIYVQNPDTHIHLEQGPSAKSGNGRALVLCSVSVACLSGLLMGYEMSLISGALLQLRDVLTLSCPEQEQVVGSLLLGAFLLSLGGGTILDHYGRRFTIILTALLCVLGTLLSVC VVSFWALVVGRMLVGMSVALSGTASCLYAAEVAPAAWRGRCVCVYELMVVLGMLLGFGLSWAFAGVPDGWRFTFGGALLPALLQAGVMPLLPDSPRFLLAQQREKEAHATLLRLRAGIKEVEPVEDELRA IRLAMGAERLHGFLDLFQSRDNMLQRLLVGAALVFLQQATGQPNILAYASTVLSSVGFHGNEAATLASTGFGVVKVGGTIPAIFLVDKVGPKALLCVGVVVMMLSTATLGAITMQSRTHVSSLCRGPGNT ANFTLFETGDETDIQTNTPLGLYQPQNKLKTNTFLTSINDTREHWILNHTYNHRTALMETAELSKKDSAKIALQSLHEVSPSLKWISLVSLLVYVAGFSISLGPMVHVVLSAIFPTGIRGKAVSVISAFN WATNLLISMTFLTLTERIGLPTVIFSYSAMSFLLVVFVIVFVPETKGRSLEQISKELAMKNHLRGTLLCHRRKHKATAQPSQEEKALATV

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q8BFW9}; Multi-pass membrane protein {Sequence Analysis}. Endomembrane system {By SimilarityUniProtKB:Q5J316}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:Q8TD20}. Note=Localizes primarily perinuclear region in the absence of insulin. {ECO:0000250\|UniProtKB:Q8TD20}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endomembrane System (GO:0012505) Membrane (GO:0016020) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Insulin-regulated facilitative glucose transporter. {Experimental EvidencePubMed:25326603}.
Assigned Ontology terms

Biological Process	Circulatory System Development (GO:0072359) Glucose Import In Response To Insulin Stimulus (GO:0044381) Glucose Transmembrane Transport (GO:1904659) Heart Contraction (GO:0060047) Heart Development (GO:0007507) Heart Valve Morphogenesis (GO:0003179) Transmembrane Transport (GO:0055085)
Molecular Function	Glucose Transmembrane Transporter Activity (GO:0005355) Symporter Activity (GO:0015293)

Cross-References

Database	Links
UNIPROT	Q6NWF1 Q6PHV4
Pfam	PF00083
PROSITE	PS50850 PS00216

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