NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Torsin-1A-interacting protein 2 - Rattus norvegicus - NucEnvDB

Torsin-1A-interacting protein 2 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Torsin-1A-interacting protein 2
Accession Code	Q6P752
Gene	Tor1aip2
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 578)
MSQTLKSQDTNMSDSGYRDPVEDSQNVLGNDPSVNSQAQDPIVTPSNTVEAQTLHPTSDLKEDHHEIGAKGQEHADTGDRAESSEEPALEKPPLDKAELERSPSSQDTEQRHHPYSEHVGGDTLVLDPNY SQSDLGGRADAHLESSSAAPTEGAGEGGEAGAHLESSCAALPVGADEGGRANAHLESSSAAPTEGAGEGGEADVHLESSSAVPPEEAHLESSSAAPSEGAGEGGEADAHLESSSAAPSEGAGEGGETAQN LLAVDSTDAQSPCHSSAGPGSQDSLRRRLPVTEAERHEEETQLVTEKEEVAQETLRKTEKKSLWTYGSMFLGCLIVAVVLSSVNSYYSSPAQQVPQNPALEAFLAQFSQLREKFPGQSAFLWQRGRKFLQ KHLNASNPSEPATVIFTAAREGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDTVKLLVDLELSYGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVSPR ETEEKVRDLLWAKFTDSGTPSSFSHMDSDKLSGLWSRISHLVLPVQPVKNIEERGCLL

Subcellular Location

Description
Endoplasmic reticulum membrane {By Similarity}; Single-pass membrane protein {By Similarity}. Nucleus envelope {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Membrane (GO:0016020) Nuclear Envelope (GO:0005635)

Biology & Function

Description
Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Endoplasmic Reticulum Organization (GO:0007029) Membrane Organization (GO:0061024) Positive Regulation Of ATP-Dependent Activity (GO:0032781) Protein Localization To Nuclear Envelope (GO:0090435)
Molecular Function	ATPase Activator Activity (GO:0001671) ATPase Binding (GO:0051117)

Cross-References

Database	Links
UNIPROT	Q6P752
Pfam	PF05609

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