NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase TRIM37 - Mus musculus - NucEnvDB

E3 ubiquitin-protein ligase TRIM37 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase TRIM37
Accession Code	Q6PCX9
Gene	Trim37
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 961)
MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFK PLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFV TTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYL NRQNDTVILRFQVRSPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDSPETRTKKAGSCSDMLLEGGPTCASVRETKEDEDEEEKIQNEDYHHELSDGDLD LDLVGEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNSMELEEGELMEDAAAAGPPGSSHSYVGASSRMSRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGLQPRPSASLLQPT ASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKTTLSDIKGSSVASTDMQTNLFCADQAALTTCGPENSGRLQDLGMELLAKSSVAGCYIRNPTNKKNSPKSARAIAGSLSLRRAVDSG ENSRSKGDCQVLAEGSSGSSQSGSRHSSPRALTHGIIGDLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVTLGTNAKGGRLEGMQMADLESHSEAGEVQPTLPEGASAAPEEGMSSDSDIECDTE NEEQEEHTSMGAFNDPFLAQPPDEDSHSSFPDGEQIDPENLHFNPDEGGGR

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:O94972}. Peroxisome {By SimilarityUniProtKB:O94972}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {By SimilarityUniProtKB:O94972}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Aggresome (GO:0016235) Cytoplasm (GO:0005737) Cytosol (GO:0005829) ESC/E(Z) Complex (GO:0035098) Perinuclear Region Of Cytoplasm (GO:0048471) Peroxisome (GO:0005777)

Biology & Function

Description
E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). {By SimilarityUniProtKB:O94972, Experimental EvidencePubMed:25470042}.
Assigned Ontology terms

Biological Process	Aggresome Assembly (GO:0070842) Histone H2A Monoubiquitination (GO:0035518) Histone H2A-K119 Monoubiquitination (GO:0036353) Negative Regulation Of Centriole Replication (GO:0046600) Negative Regulation Of NF-KappaB Transcription Factor Activity (GO:0032088) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Positive Regulation Of DNA-Binding Transcription Factor Activity (GO:0051091) Positive Regulation Of NF-KappaB Transcription Factor Activity (GO:0051092) Protein Autoubiquitination (GO:0051865)
Molecular Function	Chromatin Binding (GO:0003682) Protein Homodimerization Activity (GO:0042803) Transcription Coactivator Activity (GO:0003713) Tumor Necrosis Factor Receptor Binding (GO:0005164) Ubiquitin Protein Ligase Activity (GO:0061630) Ubiquitin Protein Ligase Binding (GO:0031625) Ubiquitin-Protein Transferase Activity (GO:0004842) Zinc Ion Binding (GO:0008270)

Cross-References

Database	Links
UNIPROT	Q6PCX9 Q5SX31 Q8CHC5
Pfam	PF00917 PF00643
PROSITE	PS50144 PS50119 PS50089

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