NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Melanoma-associated antigen E1 - Mus musculus - NucEnvDB

Melanoma-associated antigen E1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Melanoma-associated antigen E1
Accession Code	Q6PCZ4
Gene	Magee1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 918)
MSLVSQNSRRRRGGRANARRNNGKGHPAAVPGPDVPRDRNDPKILQGLRASEGPGTSMLPTPREGPSASVPPTASEGSSAPRQFIISQGPNTSEMPTSRKGRGASRPPAVSAGLNTAMSITASEGPNSPV PPTAPKGSKAYEHLPVSEGLAISEQRHSDGGPNMEPTLGEGPGISVPPTFSEESGISDEGLSIFMSPNISEGPGINEPYSVSEDPSTSVPPTDSNGLGINLPPTFGEGLSISMLFSALEEPDIFAPPPSA EGLFASMSPPSGEIQSSWVSPIIMEGCNVNVPPTSKKGLRTSVPSAACESPSTSAEGLSSSLSSISAEGFCSSLAPCAAEGSCELLPCGEGRSTSELHCLGEGSSTSQMSLAAEGPSASGMPTEANNPEE ALSCCASERRNKSTSRALQKAKDPSVRPKREDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELLQFLLLKDQTKYPIKESDMREFIDKDYRHQFPEILRRAAVHLECIFRFELKELD TEEHIYILLNKLGPVPFEGLEDVPNGPKMGLLMMILGHILLNGNQAREADIWEMLWRFGVQRERRLSVFGNVKRLLSVEFVWQRYLDYRPLTDCVPVEYEFYWGPRSRAETTKMKILKFMAKIYNKDPMD WPALYNEALEEDADRVVVNNFRVARPFRRPLFAEVAPELDASGSKYSPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRRE MEDTEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQNGRKHVITCRYLSQRYLDSLRVPDSDPVQYDFVWGPRARLETSKMKALRYVARIHRKEPEDWPEQYREAMEDEANRAEAGRR PLIVRNLR

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:14623885}. Nucleus {Experimental EvidencePubMed:14623885}. Cell membrane {Experimental EvidencePubMed:14623885}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Dendrite (GO:0030425) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Membrane (GO:0045211)

Biology & Function

Description
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122)
Molecular Function

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8BP00	IQ calmodulin-binding motif-containing protein 1	EBI-4283417	0.35

Cross-References

Database	Links
UNIPROT	Q6PCZ4 Q8BG82 Q8BQ37 Q99PB2
Pfam	PF01454
PROSITE	PS50838

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