NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Kinesin heavy chain isoform 5A - Rattus norvegicus - NucEnvDB

Kinesin heavy chain isoform 5A (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Kinesin heavy chain isoform 5A
Accession Code	Q6QLM7
Gene	Kif5a
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1027)
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNG TIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDK NRVPFVRGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENIETEQKLSGKLYLADLAGSEKVS KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMF GQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALAAEICEETPVN DNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA KEEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESEPQRLQEVSGHQRKRIAEVLNGLMKDLSE FSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKI RSLTEYMQTVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDE INEKQKTIDELKDLDQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKL FVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTEVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALK EAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQ AAPSSTSDVYFASNGATSVAPLASYQKANTDNGNATDINDNRSDLPCGYEAEDPAKLFPLHQETAAS

Structure Viewer (PDB: 3KIN)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:7514426}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:7514426}. Perikaryon {Experimental EvidencePubMed:7514426}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Apical Dendrite (GO:0097440) Axon (GO:0030424) Axon Cytoplasm (GO:1904115) Central Region Of Growth Cone (GO:0090724) Ciliary Rootlet (GO:0035253) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendrite (GO:0030425) Dendrite Cytoplasm (GO:0032839) Kinesin Complex (GO:0005871) Microtubule (GO:0005874) Neuron Projection (GO:0043005) Neuronal Cell Body (GO:0043025) P-Body (GO:0000932) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431). {By SimilarityUniProtKB:P33175, Experimental EvidencePubMed:23576431}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Protein Transport (GO:0099641) Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex (GO:0098971) Axon Guidance (GO:0007411) Cellular Response To Ethanol (GO:0071361) Cellular Response To Nerve Growth Factor Stimulus (GO:1990090) Cerebral Cortex Development (GO:0021987) Cytoskeleton-Dependent Intracellular Transport (GO:0030705) Hippocampus Development (GO:0021766) Microtubule-Based Movement (GO:0007018) Microtubule-Based Process (GO:0007017) Neuron Development (GO:0048666) Response To Rotenone (GO:1904647) Retrograde Neuronal Dense Core Vesicle Transport (GO:1990049) Synaptic Vesicle Transport (GO:0048489) Thalamus Development (GO:0021794) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Kinesin Binding (GO:0019894) Microtubule Binding (GO:0008017) Microtubule Motor Activity (GO:0003777) Plus-End-Directed Microtubule Motor Activity (GO:0008574) Protein-Containing Complex Binding (GO:0044877) Scaffold Protein Binding (GO:0097110)

Protein-Protein Interactions

Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
O70585	Dystrobrevin beta (DTN-B) (mDTN-BDTN-B) (Beta-dystrobrevin)	EBI-8053419	0.35
P04688	Tubulin alpha-1 chain (EC 3.6.5.-)	EBI-15728888	0.49
P05219	Tubulin beta chain (Beta-tubulin)	EBI-15728888	0.49
Q10113	Microtubule integrity protein mal3	EBI-15728926	0.49
Q03555	Gephyrin (Putative glycine receptor-tubulin linker protein) [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]	EBI-15780606	0.35
P07727	Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)	EBI-15780624	0.35
Q5XIE8	Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]	EBI-26438079	0.35

Cross-References

Database	Links
UNIPROT	Q6QLM7
PDB	2KIN 3KIN
Pfam	PF00225
PROSITE	PS50067

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