NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Pleckstrin homology domain-containing family G member 5 - Rattus norvegicus - NucEnvDB

Pleckstrin homology domain-containing family G member 5 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Pleckstrin homology domain-containing family G member 5
Accession Code	Q6RFZ7
Gene	Plekhg5
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1039)
MDKGRAAKVCHHADCQQLHHRGPLNLCEICDSKFHNTTHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAGDLEEEDEGYTNGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPA MKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGTPVLERVDPQSRRESSLDILAPGRRRKNMSEFLGDTSIPGQESPAPSS CSLPVGSSVGSSGSSESWKNRAASRFSGFFSSSPSTGAFGREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEDDEEEEDNSGLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEVSYIRK LRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPELARLHRGLWSSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP HQRLTKYPLLLKSVLRKTDEPRAKEAIITMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKFLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLV TKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQALCRSWVDTLYNAQNQLQQLRAQLLCAQEHPGTQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEH CASDGSTETLAMVVVEPGETLSSPEFDRGPFSSQSDEASLSNTTSSITPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFAAPHPVVEPVPVPQTLSPQPSPRLRRRTPVQLLPRLPHLLKSKSEASLL QLLSGTTTSVSPPAPSRSLSELCLITMAPGVRTQSSLQEGGPGWNCPGACGPCQGPPLSESENRPSHKAGGPADSARRKCREMPCGTVPRVQPEPSPGISAQHRKLTLAQLYRIRTTLLLNSTLTASEV

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:16467373}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:16467373}. Cell membrane {Experimental EvidencePubMed:16467373}. Cell junction {ECO:0000250\|UniProtKB:Q66T02}. Cell projection, lamellipodium {ECO:0000250\|UniProtKB:Q66T02}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250\|UniProtKB:Q66T02, Experimental EvidencePubMed:16467373}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Cell-Cell Junction (GO:0005911) Cytoplasm (GO:0005737) Endocytic Vesicle (GO:0030139) Lamellipodium (GO:0030027) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Presynapse (GO:0098793)

Biology & Function

Description
Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity). {By SimilarityUniProtKB:O94827, By SimilarityUniProtKB:Q66T02}.
Assigned Ontology terms

Biological Process	Endothelial Cell Chemotaxis (GO:0035767) Endothelial Cell Migration (GO:0043542) Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission (GO:0099575) Rho Protein Signal Transduction (GO:0007266)
Molecular Function	Guanyl-Nucleotide Exchange Factor Activity (GO:0005085)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Z254	PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin)	EBI-9079906	0.46

Cross-References

Database	Links
UNIPROT	Q6RFZ7
Pfam	PF00621
PROSITE	PS50010 PS50003

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