NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Leucine-rich repeat transmembrane protein FLRT1 - Mus musculus - NucEnvDB

Leucine-rich repeat transmembrane protein FLRT1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Leucine-rich repeat transmembrane protein FLRT1
Accession Code	Q6RKD8
Gene	Flrt1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 646)
MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHL DDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYN TLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGGAANAAAKTTVSNHASATTPQGSLFTLKAKRPG LRLPDSNIDYPMATGDGAKTLVIQVKPLTADSIRITWKAMLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETGNTYVADETPVCAKAETADSYGPTTTLNQEQNAGPM AGLPLAGIIGGAVALVFLFLVLGAICWYVHRAGELLTRERVYNRGSRRKDDYMESGTKKDNSILEIRGPGLQMLPINPYRSKEEYVVHTIFPSNGSSLCKGAHTIGYGTTRGYREAGIPDVDYSYT

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:16872596, Experimental EvidencePubMed:20421966, Experimental EvidencePubMed:22405201}; Single-pass membrane protein {Curator Inference}. Endoplasmic reticulum membrane {Curator Inference\|PubMed:16872596, Curator Inference\|PubMed:20421966}. Cytoplasmic vesicle membrane {Experimental EvidencePubMed:16872596, Experimental EvidencePubMed:20421966}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:16872596, Experimental EvidencePubMed:20421966}. Cell junction, focal adhesion {Experimental EvidencePubMed:16872596}. Secreted {ECO:0000269\|PubMed:21673655}. Cell projection, neuron projection {Experimental EvidencePubMed:20421966}. Cell junction {Experimental EvidencePubMed:20421966}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles (PubMed:16872596, PubMed:20421966). Detected along neurites and at contacts between neurite termini and other cells (PubMed:20421966). Proteolytic cleavage gives rise to a shedded ectodomain (PubMed:21673655). {Experimental EvidencePubMed:16872596, Experimental EvidencePubMed:20421966, ECO:0000269\|PubMed:21673655}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cell-Cell Junction (GO:0005911) Cytoplasmic Vesicle (GO:0031410) Cytoplasmic Vesicle Membrane (GO:0030659) Endoplasmic Reticulum Membrane (GO:0005789) Extracellular Space (GO:0005615) Focal Adhesion (GO:0005925) Neuron Projection Terminus (GO:0044306) Neuronal Cell Body Membrane (GO:0032809) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases (PubMed:16872596, PubMed:20421966). Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length (PubMed:20421966). May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3 (PubMed:22405201). {Experimental EvidencePubMed:16872596, Experimental EvidencePubMed:20421966, Curator InferencePubMed:22405201}.
Assigned Ontology terms

Biological Process	Cell Adhesion (GO:0007155) Dendrite Development (GO:0016358) Fibroblast Growth Factor Receptor Signaling Pathway (GO:0008543) Neuron Projection Extension (GO:1990138) Positive Regulation Of Synapse Assembly (GO:0051965)
Molecular Function	Fibroblast Growth Factor Receptor Binding (GO:0005104)

Cross-References

Database	Links
UNIPROT	Q6RKD8 Q14DT7 Q6RKD9
Pfam	PF13855 PF01462
PROSITE	PS50853 PS51450

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK