NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cytoplasmic polyadenylation element-binding protein 4 - Danio rerio - NucEnvDB

Cytoplasmic polyadenylation element-binding protein 4 (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Cytoplasmic polyadenylation element-binding protein 4
Accession Code	Q7SXN4
Gene	cpeb4
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 635)
MQDDILESEMSKAPQLQQESQEGQDKQTLSPPGHQEPPGIISELDNALPEENQLEKGTMENANGKETLRLESPVLSGFDYQETTGIGTLAQSSSSSSSSLTGFSSWSTAMPPNPSTLIEEVGFFNQAATT NNAPPPLLFQSFSHHTSTGFGGNFSHQIGPLSQHHPSPHPHFQHPHNQHRRSSASPHPPPFSHRSAAFNQLPHLGNNLSKPPSPWGSYQSPSSTPSSTSWSPGGGYGGWGSSQGREYRRGGVNPLNSISP LKKSFPNNQTQTQKYPRNNSGFNTKPWVEDTINRNESIFPFQERSRSFDGFSMHSLENSLIDIMRAEQDSLKGHSSLFPMEDERSYGEDERSDQSLSGLGSPHSFPHQNGERIERYSRKVFVGGLPPDID EDEITASFRRFGHLFVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACMEEDGKLYLCVSSPTIKDKPVQIRPWNLNDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDT DPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q7TN98}. Cell projection, dendrite {By SimilarityUniProtKB:Q7TN98}. Cell projection, dendritic spine {By SimilarityUniProtKB:Q7TN98}. Postsynaptic density {By SimilarityUniProtKB:Q7TN98}. Cell projection, axon {By SimilarityUniProtKB:Q7TN98}. Cell projection, growth cone {By SimilarityUniProtKB:Q7TN98}. Endoplasmic reticulum {By SimilarityUniProtKB:Q7TN98}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q7TN98}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Dendrite (GO:0030425) Dendritic Spine (GO:0043197) Endoplasmic Reticulum (GO:0005783) Growth Cone (GO:0030426) Messenger Ribonucleoprotein Complex (GO:1990124) Neuron Projection (GO:0043005) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynaptic Density (GO:0014069) Synapse (GO:0045202)

Biology & Function

Description
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. {By SimilarityUniProtKB:Q17RY0}.
Assigned Ontology terms

Biological Process	Cellular Response To Amino Acid Stimulus (GO:0071230) Cellular Response To Decreased Oxygen Levels (GO:0036294) Cellular Response To Glucose Starvation (GO:0042149) Ionotropic Glutamate Receptor Signaling Pathway (GO:0035235) Negative Regulation Of Cytoplasmic Translation (GO:2000766) Negative Regulation Of Neuron Apoptotic Process (GO:0043524) Response To Ischemia (GO:0002931)
Molecular Function	MRNA 3'-UTR Binding (GO:0003730) MRNA Regulatory Element Binding Translation Repressor Activity (GO:0000900) Ribosome Binding (GO:0043022) Translation Factor Activity, RNA Binding (GO:0008135)

Cross-References

Database	Links
UNIPROT	Q7SXN4
Pfam	PF16366 PF16367
PROSITE	PS50102

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