NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein TAMALIN - Homo sapiens - NucEnvDB

Protein TAMALIN (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Protein TAMALIN
Accession Code	Q7Z6J2
Gene	TAMALIN
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 395)
MTLRRLRKLQQKEEAAATPDPAARTPDSEVAPAAPVPTPGPPAAAATPGPPADELYAALEDYHPAELYRALAVSGGTLPR RKGSGFRWKNLSQSPEQQRKVLTLEKEDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNG LNVEGIRHREIVDIIKASGNVLRLETLYGTSIRKAELEARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTL ESVRSCLYGAGLLPGSLPFGPLLAVPGRPRGGARRARGDADDAVYHTCFFGDSEPPALPPPPPPARAFGPGPAETPAVGP GPGPRAALSRSASVRCAGPGGGGGGGAPGALWTEAREQALCGPGLRKTKYRSFRRRLLKFIPGLNRSLEEEESQL

Structure Viewer (PDB: 2PNT)

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q8R4T5}. Cell membrane {By SimilarityUniProtKB:Q8R4T5}; Peripheral membrane protein {By SimilarityUniProtKB:Q8R4T5}; Cytoplasmic side {By SimilarityUniProtKB:Q8R4T5}. Postsynaptic cell membrane {By SimilarityUniProtKB:Q8R4T5}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q8R4T5}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Glutamatergic Synapse (GO:0098978) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Density (GO:0014069) Postsynaptic Membrane (GO:0045211) Schaffer Collateral - CA1 Synapse (GO:0098685)

Biology & Function

Description
Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {By Similarity}.
Assigned Ontology terms

Biological Process	Protein Localization (GO:0008104) Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane (GO:0099152) Signal Transduction (GO:0007165)
Molecular Function	Identical Protein Binding (GO:0042802) PDZ Domain Binding (GO:0030165) Small GTPase Binding (GO:0031267)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q5NHN0	4-alpha-glucanotransferase (EC 2.4.1.25) (Amylomaltase) (Disproportionating enzyme)	EBI-2806502	0.00
Q9BYF1	Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]	EBI-28949723	0.40

Cross-References

Database	Links
UNIPROT	Q7Z6J2 Q6PIF8 Q7Z741
PDB	2PNT
Pfam	PF00595
PROSITE	PS50106
OMIM	612027
DisGeNET	160622

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