NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

N-alpha-acetyltransferase 15, NatA auxiliary subunit - Mus musculus - NucEnvDB

N-alpha-acetyltransferase 15, NatA auxiliary subunit (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	N-alpha-acetyltransferase 15, NatA auxiliary subunit
Accession Code	Q80UM3
Gene	Naa15
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 865)
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRDL EGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPGNWAY YKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDRFLRMNFSKGCPPVFNTLRSLYRDKEKVAIVEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQP SIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYVLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITD DQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKV ETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSGHPWLHECMIRLFHSVCESKDLPETVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDSSSQK RAIELATTLDGSLTNRNLQTCMEVLEALCDGSLGDCKEAAEAYRASCHKLFPYALAFMPPGYEEDMKITVNGDSSAETEELANEI

Subcellular Location

Description
Cytoplasm {By Similarity}. Nucleus {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton- bound polysomes, but not in the membrane-bound polysomes. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Intracellular Membrane-Bounded Organelle (GO:0043231) NatA Complex (GO:0031415) Nuclear Body (GO:0016604) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Transcription Regulator Complex (GO:0005667)

Biology & Function

Description
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {Experimental EvidencePubMed:10842358, Experimental EvidencePubMed:12145306, Experimental EvidencePubMed:12888564, Experimental EvidencePubMed:15452080}.
Assigned Ontology terms

Biological Process	Angiogenesis (GO:0001525) Cell Differentiation (GO:0030154) N-Terminal Peptidyl-Methionine Acetylation (GO:0017196) N-Terminal Protein Amino Acid Acetylation (GO:0006474) Negative Regulation Of Apoptotic Process (GO:0043066) Positive Regulation Of DNA-Templated Transcription (GO:0045893) Protein Stabilization (GO:0050821)
Molecular Function	Acetyltransferase Activity (GO:0016407) N-Acetyltransferase Activity (GO:0008080) Ribosome Binding (GO:0043022)

Protein-Protein Interactions

Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9GZZ1	N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit)	EBI-2563502	0.40
Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)	EBI-2563502	0.40
Q9NX55	Huntingtin-interacting protein K (Huntingtin yeast partner K)	EBI-2563502	0.40
P41227	N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)	EBI-2563502	0.40
Q6NZM9	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-26472137	0.35
Q9CQE6	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A)	EBI-26472808	0.35

Cross-References

Database	Links
UNIPROT	Q80UM3 Q811Z9 Q9JID5
Pfam	PF12569 PF13181
PROSITE	PS50005 PS50293

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK