NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein LYRIC - Mus musculus - NucEnvDB

Protein LYRIC (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Protein LYRIC
Accession Code	Q80WJ7
Gene	Mtdh
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 579)
MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAPPTPAPDDLAQLKNLRSEEQKKKNRKKLPEKPKPNGR TVEVPEDEVVRNPRSITAKQAPETDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENIITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFK SGKGDSTLQVSSRLNENLTVNGGGWSEKSVKLSSQLSEEKWNSVPPASAGKRKTEPSAWTQDTGDTNANGKDWGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSD WNAPAEEWGNWVDEDRASLLKSQEPISNDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSHTQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPAEVLIKNSQPVKTLPPAISAEPSIT LSKGDSDNSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET

Subcellular Location

Description
Endoplasmic reticulum membrane {By Similarity}; Single-pass membrane protein {By Similarity}. Nucleus membrane {By Similarity}; Single-pass membrane protein {By Similarity}. Cell junction, tight junction {By Similarity}. Nucleus, nucleolus {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF- alpha causes translocation from the cytoplasm to the nucleus (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Nuclear Membrane	SL-0182	The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Bicellular Tight Junction (GO:0005923) Cytoplasm (GO:0005737) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Fibrillar Center (GO:0001650) Intercellular Canaliculus (GO:0046581) Nuclear Body (GO:0016604) Nuclear Membrane (GO:0031965) Nucleolus (GO:0005730) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Lipopolysaccharide-Mediated Signaling Pathway (GO:0031663) Negative Regulation Of Apoptotic Process (GO:0043066) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Positive Regulation Of Angiogenesis (GO:0045766) Positive Regulation Of Autophagy (GO:0010508) Positive Regulation Of I-KappaB Kinase/NF-KappaB Signaling (GO:0043123) Positive Regulation Of NF-KappaB Transcription Factor Activity (GO:0051092) Positive Regulation Of Protein Kinase B Signaling (GO:0051897) Regulation Of Transcription By RNA Polymerase II (GO:0006357)
Molecular Function	Double-Stranded RNA Binding (GO:0003725) NF-KappaB Binding (GO:0051059) RNA Polymerase II-Specific DNA-Binding Transcription Factor Binding (GO:0061629) Transcription Coactivator Activity (GO:0003713) Transcription Coregulator Activity (GO:0003712)

Protein-Protein Interactions

Interactions with other proteins (4 interactors)

Partner (UniProt)		IntAct	Confidence score
Q78PY7	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (p100 co-activator)	EBI-9682947	0.52
P70326	T-box transcription factor TBX5 (T-box protein 5)	EBI-16360068	0.35
P11531	Dystrophin	EBI-20567174	0.35
Q6NZM9	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-26472902	0.35

Cross-References

Database	Links
UNIPROT	Q80WJ7 B2RSG8 Q05CM0 Q3U9F8 Q3UAQ8 Q8BN67 Q8CBT9 Q8CDL0 Q8CGI7 Q9D052
Pfam	PF15686

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