NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Serine/threonine-protein kinase LMTK1 - Mus musculus - NucEnvDB

Serine/threonine-protein kinase LMTK1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Serine/threonine-protein kinase LMTK1
Accession Code	Q80YE4
Gene	Aatk
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1365)
MSSSFFNPSFAFSSHFDPDGAPLSELSWSSSLAVVAVSFSGIFTVVILMLACLCCKKGGIGFKEFENAEGDEYVADFSEQGSPAAAAQTGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDLGRHSLLYLK EIGHGWFGKVFLGEVHSGVSGTQVVVKELKVSASVQEQMQFLEEAQPYRALQHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVTESMAPDPLTLQRMACEVACGVLHLHRHNYVHSDLALRNC LLTADLTVKVGDYGLSHCKYREDYLVTADQLWVPLRWIAPELVDEVHGNLLVVDQTKSSNVWSLGVTIWELFELGAQPYPQHSDRQVLAYAVREQQLKLPKPQLQLALSDRWYEVMQFCWLQPEQRPTAE EVHLLLSYLCAKGTTELEEEFERRWRSLRPGGSTGLGSGSAAPAAATAASAELTAASSFPLLERFTSDGFHVDSDDVLTVTETSHGLNFEYKWEAGCGAEEYPPSGAASSPGSAARLQELCAPDSSPPGV VPVLSAHSPSVGSEYFIRLEGAVPAAGHDPDCAGCAPSPQAVTDQDNNSEESTVASLAMEPLLGHAPPTEGLWGPCDHHSHRRQGSPCPSRSPSPGTPMLPAEDIDWGVATFCPPFFDDPLGASPSGSPG AQPSPSDEEPEEGKVGLAAQCGHWSSNMSANNNSASRDPESWDPGYVSSFTDSYRDDCSSLEQTPRASPEVGHLLSQEDPRDFLPGLVAVSPGQEPSRPFNLLPLCPAKGLAPAACLITSPWTEGAVGGA ENPIVEPKLAQEAEGSAEPQLPLPSVPSPSCEGASLPSEEASAPDILPASPTPAAGSWVTVPEPAPTLESSGSSLGQEAPSSEDEDTTEATSGVFTDLSSDGPHTEKSGIVPALRSLQKQVGTPDSLDSL DIPSSASDGGCEVLSPSAAGPPGGQPRAVDSGYDTENYESPEFVLKEAHESSEPEAFGEPASEGESPGPDPLLSVSLGGLSKKSPYRDSAYFSDLDAESEPTFGPEKHSGIQDSQKEQDLRSPPSPGHQS VQAFPRSAVSSEVLSPPQQSEEPLPEVPRPEPLGAQGPVGVQPVPGPSHSKCFPLTSVPLISEGSGTEPQGPSGQLSGRAQQGQMGNPSTPRSPLCLALPGHPGALEGRPEEDEDTEDSEESDEELRCYS VQEPSEDSEEEPPAVPVVVAESQSARNLRSLLKMPSLLSEAFCDDLERKKKAVSFFDDVTVYLFDQESPTRETGEPFPSTKESLPTFLEGGPSSPSATGLPLRAGHSPDSSAPEPGSRFEWDGDFPLVPG KAALVTELDPADPVLAAPPTPAAPFSRFTVSPTPASRFSITHISDSDAQSVGGPAAGAGGRYTEA

Subcellular Location

Description
Membrane {Experimental EvidencePubMed:17651901}; Single- pass type I membrane protein {Experimental EvidencePubMed:17651901}. Cytoplasm {Experimental EvidencePubMed:17651901}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, dendrite {Experimental EvidencePubMed:17651901}. Cell projection, axon {Experimental EvidencePubMed:17651901}. Cell projection, growth cone {Experimental EvidencePubMed:17651901}. Note=Predominantly perinuclear. {ECO:0000250}. [Isoform 2]: Membrane. Note=Peripheral membrane protein. [Isoform 3]: Membrane; Single-pass type I membrane protein.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Dendrite (GO:0030425) Growth Cone (GO:0030426) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
May be involved in neuronal differentiation. {By Similarity}.
Assigned Ontology terms

Biological Process	Apoptotic Process (GO:0006915) Brain Development (GO:0007420) Neuron Apoptotic Process (GO:0051402) Peptidyl-Tyrosine Autophosphorylation (GO:0038083) Protein Phosphorylation (GO:0006468)
Molecular Function	ATP Binding (GO:0005524) Protein Kinase Activity (GO:0004672) Protein Serine Kinase Activity (GO:0106310) Protein Serine/Threonine Kinase Activity (GO:0004674) Protein Tyrosine Kinase Activity (GO:0004713)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Z1W9	STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (Serine/threonine-protein kinase 39)	EBI-1768690	0.37

Cross-References

Database	Links
UNIPROT	Q80YE4 A6BLY8 O35211 Q3U2U5 Q3UHR8 Q66JN3 Q80YE3 Q8CB63 Q8CHE2
Pfam	PF07714
PROSITE	PS00107 PS50011 PS00109

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