NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Serine incorporator 5 - Homo sapiens - NucEnvDB

Serine incorporator 5 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Serine incorporator 5
Accession Code	Q86VE9
Gene	SERINC5
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 423)
MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSAVYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFK LLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKWNKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSG LLQSGVISCYVTYLTFSALSSKPAEVVLDEHGKNVTICVPDFGQDLYRDENLVTILGTSLLIGCILYSCLTSTTRSSSDALQGRYAAPELEIARCCFCFSPGGEDTEEQQPGKEGPRVIYDEKKGTVYIY SYFHFVFFLASLYVMMTVTNWFNHVRSAFHLLP

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:26416733, Experimental EvidencePubMed:26416734}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:26416734, ECO:0000305\|PubMed:26416733}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (PubMed:26416733, PubMed:26416734). Localizes to the cell membrane, where it is efficiently incorporated into budding virions and impairs subsequent virion entry into target cells (PubMed:26416733, PubMed:26416734). {Experimental EvidencePubMed:26416734, ECO:0000305\|PubMed:26416733}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Centrosome (GO:0005813) Cytosol (GO:0005829) Extracellular Exosome (GO:0070062) Golgi Apparatus (GO:0005794) Intracellular Membrane-Bounded Organelle (GO:0043231) Membrane (GO:0016020) Myelin Sheath (GO:0043209) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {By SimilarityUniProtKB:Q63175, Experimental EvidencePubMed:26416733, Experimental EvidencePubMed:26416734}.
Assigned Ontology terms

Biological Process	Defense Response To Virus (GO:0051607) Detection Of Virus (GO:0009597) Innate Immune Response (GO:0045087) L-Serine Biosynthetic Process (GO:0006564) Myelination (GO:0042552) Phosphatidylserine Metabolic Process (GO:0006658) Phospholipid Biosynthetic Process (GO:0008654) Positive Regulation Of CDP-Diacylglycerol-Serine O-Phosphatidyltransferase Activity (GO:1904219) Positive Regulation Of Serine C-Palmitoyltransferase Activity (GO:1904222) Sphingolipid Metabolic Process (GO:0006665)
Molecular Function	L-Serine Transmembrane Transporter Activity (GO:0015194)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P88995	58 protein (Uncharacterized protein GAMMAHV.ORF58)	EBI-9641349	0.37
P25105	Platelet-activating factor receptor (PAF-R) (PAFr)	EBI-20811174	0.37

Cross-References

Database	Links
UNIPROT	Q86VE9 B4DMH7 Q495A4 Q495A6
Pfam	PF03348
OMIM	614551
DisGeNET	256987

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