NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase RNF128 - Xenopus laevis - NucEnvDB

E3 ubiquitin-protein ligase RNF128 (Xenopus laevis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase RNF128
Accession Code	Q8AWW4
Gene	rnf128
Organism	Xenopus laevis \| African clawed frog (Taxonomy: 8355)
Part of Reference Proteome?	Yes
Sequence (Length: 404)
MGALKMRCQCFPLPYLSLLALLLLNLSLTRAETLWTANVNYSYVYDNKTYGEEGEIGVFGQDSPIERAAGLVVLPKSEKLYTACKDNVNFSVPSGWTGPWIALIQRGGGCTFTEKINRAAERGARAVVVY NNGIDNEVFEMSHPGTKDTVAIMIGNLKGNEIVDLIKGGMQVTMVIEVGRKHGSWINHYSIFFVSVSFFIVTAATVGYFIFYSARRWRLTRAQNKKQKRLKAEAKKAIGKLQLRTIKQGDKVLGPDGDSC AVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLEHRTCPMCKCDILKSLGIAEDEEEGTSVAIPSVSSELQRSTVQITEEENHSETASSGYASVRGGDEQVDEGQHIYENTELVHEASATSIEVLPHMDNP GFESEDVHVHEMKS

Subcellular Location

Description
Endomembrane system {By Similarity}; Single-pass membrane protein {By Similarity}. Cytoplasm, perinuclear region {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endomembrane System (GO:0012505) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains (By similarity). Converts epidermis into cement gland and neural tissue in whole embryos. {By Similarity, Experimental EvidencePubMed:12435366}.
Assigned Ontology terms

Biological Process	Protein Ubiquitination (GO:0016567)
Molecular Function	Metal Ion Binding (GO:0046872) Transferase Activity (GO:0016740)

Cross-References

Database	Links
UNIPROT	Q8AWW4
Pfam	PF02225 PF13639
PROSITE	PS50089

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