National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Serine/threonine-protein kinase VRK2 |
| Accession Code | Q8BN21 |
| Gene | Vrk2 |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 503) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249). Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen- activated protein kinase (MAPK) complexes (By similarity). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (By similarity). Phosphorylates histone H3 (By similarity). Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity (By similarity). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain- containing proteins (By similarity). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (By similarity). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (By similarity). May also phosphorylate MAPK8IP1 (By similarity). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity). {By SimilarityUniProtKB:Q86Y07, Experimental EvidencePubMed:14645249}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q8BN21 Q3U415 Q5F1Z5 Q5SP88 Q8BPU8 Q8CJ46 Q91WS1 Q9CZF9 |
| Pfam | PF00069 |
| PROSITE | PS50011 PS00108 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory