NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Fidgetin-like protein 1 - Mus musculus - NucEnvDB

Fidgetin-like protein 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Fidgetin-like protein 1
Accession Code	Q8BPY9
Gene	Fignl1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 683)
METSSSMSVETTRSVQVDEWQKNYCVVTSSICTPKQKADAYRALLLHIQYAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSRQADSNKWQSGLSIDNVFKMSCVQEMMQAGK KFEESLLEPADASVVLCKEPTAFEVPQLSVCGGSEDADILSSSGHDTDKTQAIPGSSLRCSPFQSARLPKETNTTKTCLTSSTSLGESATAAFHMTPLFGNTEKDTQSFPKTSTGLNMFLSNLSCVPSGC ENPQERKAFNDSDIIDILSNPTLNKAPSKTEDRGRREDNSLPTFKTAKEQLWVDQKKKGHQSQHTSKSSNGVMKKSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKSSRAGSAEPAHLTDDCLKNVEP RMVELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGD GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVGNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIATISPDQVRPIAY IDFENAFKTVRPTVSPKDLELYENWNETFGCGK

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:Q6PIW4}. Cytoplasm {Experimental EvidencePubMed:22110678}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:22110678}. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage- induced foci after ionizing radiation (IR) treatment. {By SimilarityUniProtKB:Q6PIW4}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nuclear Chromosome (GO:0000228) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:17352653). May play a role in the control of male meiosis dynamic (PubMed:22110678). {By SimilarityUniProtKB:Q6PIW4, Experimental EvidencePubMed:17352653, Experimental EvidencePubMed:22110678}.
Assigned Ontology terms

Biological Process	ATP Metabolic Process (GO:0046034) Cellular Response To Ionizing Radiation (GO:0071479) Male Meiotic Nuclear Division (GO:0007140) Negative Regulation Of Apoptotic Process (GO:0043066) Negative Regulation Of Intrinsic Apoptotic Signaling Pathway (GO:2001243) Osteoblast Differentiation (GO:0001649) Osteoblast Proliferation (GO:0033687) Regulation Of Cell Cycle (GO:0051726) Regulation Of Double-Strand Break Repair Via Homologous Recombination (GO:0010569)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Hydrolase Activity (GO:0016787) Magnesium Ion Binding (GO:0000287) Microtubule Severing ATPase Activity (GO:0008568)

Cross-References

Database	Links
UNIPROT	Q8BPY9 Q3UF48 Q8C2I6 Q9ERZ5
Pfam	PF00004 PF09336
PROSITE	PS00674

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