NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Tumor necrosis factor receptor superfamily member 19L - Mus musculus - NucEnvDB

Tumor necrosis factor receptor superfamily member 19L (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Tumor necrosis factor receptor superfamily member 19L
Accession Code	Q8BX43
Gene	Relt
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 436)
MSLQGLMMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGKEPDPDPGQGTLCRTCPPGTFSASWNSYPCQPHYRCSLQKRLEAQAGTATHDTMCGDCQHGWFGPQGVPHVPCQPCSKAPPSTGGCDE SGRRGRRGVEVAAGTSSNGEPRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQL VQTSHRPVPRLLPASPSIPHICPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPTASRAPKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSEGDLPDSP QPGLPPEQRALLGSGGSHTKWLKPPAENKAEENRYVVRLSESNLVI

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q969Z4}; Single-pass type I membrane protein {By SimilarityUniProtKB:Q969Z4}. Cytoplasm {By SimilarityUniProtKB:Q969Z4}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q969Z4}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation (PubMed:30506946). {By SimilarityUniProtKB:Q969Z4, Experimental EvidencePubMed:30506946}.
Assigned Ontology terms

Biological Process	Amelogenesis (GO:0097186) Apoptotic Process (GO:0006915)
Molecular Function

Cross-References

Database	Links
UNIPROT	Q8BX43 Q497Z8 Q8BTV0
Pfam	PF12606

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