NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Apoptosis-stimulating of p53 protein 2 - Mus musculus - NucEnvDB

Apoptosis-stimulating of p53 protein 2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Apoptosis-stimulating of p53 protein 2
Accession Code	Q8CG79
Gene	Tp53bp2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1128)
MMPMFLTVYLSNSEQHFTEVPVTPETICRDVVDLCKEPGENDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPNRDIVSGPRSQDPSVKRNGVKVPGEHRRKENGVNSPRLDLTLAE LQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAV AELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAALQQKENLPVSPDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSAEGPMKIQTL PNMRSGAASQSKGSKAHPASPDWNPSNADLLPSQGSSVPQSAGTALDQVDDGEIAVREKEKKVRPFSMFDTVDQCAAPPSFGTLRKNQSSEDILRDAQAVNKNVAKVPPPVPTKPKQIHLPYFGQTAQSP SDMKPDGNAQQLPIAATSVGAKLKPAGPQARMLLSPGAPSGGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTQPRGPHFSSVYGKPVIA AAQNPQQHPENIYSCSQGKPGSPEPETETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVN PESSVEIPNPYLHVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNVEETNPEAPHLLEVYLEEYPPYPPPPYPSGEPEVSEEDSARMRPPEITGQVSLPPGKRTNLRK TGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGY TQCSQFLYGVQEKMGIMNKGVIYALWDYEPQHDDELLMKEGDCMTVIRREDEEEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Nucleus {By Similarity}. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Junction (GO:0030054) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity). Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis- stimulating activity is inhibited by its interaction with DDX42 (By similarity). {By Similarity, By Similarity\|UniProtKB:Q13625}.
Assigned Ontology terms

Biological Process	Cell Cycle (GO:0007049) Central Nervous System Development (GO:0007417) Embryo Development Ending In Birth Or Egg Hatching (GO:0009792) Heart Development (GO:0007507) Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator (GO:0072332) Positive Regulation Of Execution Phase Of Apoptosis (GO:1900119) Positive Regulation Of Neuron Death (GO:1901216) Response To Ionizing Radiation (GO:0010212)
Molecular Function	Identical Protein Binding (GO:0042802) NF-KappaB Binding (GO:0051059) P53 Binding (GO:0002039) SH3 Domain Binding (GO:0017124)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O35626	Dexamethasone-induced Ras-related protein 1	EBI-4325310	0.37
Interactions with other proteins (4 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9EQ32	Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)	EBI-654281	0.37
P35569	Insulin receptor substrate 1 (IRS-1)	EBI-1751427	0.40
Q80YT7	Myomegalin (Phosphodiesterase 4D-interacting protein)	EBI-16732484	0.35
Q3UHD9	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)	EBI-16750831	0.35

Cross-References

Database	Links
UNIPROT	Q8CG79 Q3UYM7 Q8K2L5
Pfam	PF12796 PF14604
PROSITE	PS50297 PS50088 PS50002

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