NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Calcium homeostasis endoplasmic reticulum protein - Mus musculus - NucEnvDB

Calcium homeostasis endoplasmic reticulum protein (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Calcium homeostasis endoplasmic reticulum protein
Accession Code	Q8CGZ0
Gene	Cherp
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 936)
MEMPMPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQQQLICKQQAPELEPTSAMPPLPQPPLAPTASLTPAQGTPSMDELIQQSQWSLQQQEQHLLALRQEQ VTTAVAHAVEQQMQKLLEETQLDMSEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKI ARLLQLWEKNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQSLKTQHEEFVSSLAQQQQQQQQQQQQQPQPQPQPQIQLPQMEADVKATPPPPAPPPASAPAPTIPPTTQPDDNKP PIQMPGSSEYDTSAGVQDPAAAGPRGPGPHEQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRDAPWNNQPDPNWNNQFEGPWNNQHEPPPWGGAQRE PPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYPHRFDYPQGDFPADMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSL VPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGPSRSRSRSKSRGRSSSRSSSRSSKSSRSSSRSHSRS RSRSSSRSRSRSRSRSRSSRSRSRSRSRSRSKSYSPGRRRRSRSRSPTPPSAAGLGSNSAPPIPDSRLGEENKGHQMLVKMGWSGSGGLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNK SYSFIARMKARDEFSTFGTRKEEKED

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q8IWX8}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q8IWX8}. Endoplasmic reticulum {By SimilarityUniProtKB:Q8IWX8}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region. Colocalizes with ITPR1 (By similarity). {By SimilarityUniProtKB:Q8IWX8}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471) Sarcoplasmic Reticulum Membrane (GO:0033017)

Biology & Function

Description
Involved in calcium homeostasis, growth and proliferation. {By SimilarityUniProtKB:Q8IWX8}.
Assigned Ontology terms

Biological Process	Cellular Calcium Ion Homeostasis (GO:0006874) Negative Regulation Of Cell Population Proliferation (GO:0008285) Positive Regulation Of Calcineurin-NFAT Signaling Cascade (GO:0070886) Release Of Sequestered Calcium Ion Into Cytosol (GO:0051209) RNA Processing (GO:0006396)
Molecular Function	RNA Binding (GO:0003723) Transmembrane Transporter Binding (GO:0044325)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	EBI-2362860	0.37
Q15637	Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)	EBI-11298622	0.00
Q3UL36	Arginine and glutamate-rich protein 1	EBI-26888124	0.35

Cross-References

Database	Links
UNIPROT	Q8CGZ0 Q8K291 Q8VCD2
Pfam	PF04818 PF01585 PF01805
PROSITE	PS51391 PS50174 PS50128

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