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NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Rhophilin-2 - Canis lupus familiaris - NucEnvDB
Rhophilin-2 (
Canis lupus familiaris
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Cross-References
General Information
Protein Information
Protein Name
Rhophilin-2
Accession Code
Q8HXG3
Gene
RHPN2
Organism
Canis lupus familiaris
| Dog (Taxonomy:
9615
)
Part of Reference Proteome?
Yes
Sequence (Length: 686)
Show
MTDALLPAAPQPLEKESDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNHKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQSTEEAFTVPLIPLGLKETKDIDFSVVLK
DFILEHYSEDSYLYEDEIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRQMGILFTWYDSLTGVPVSQQNLLLEKASILFNIGALYTQIGTRCNRRTQAGLDGAVDAFQRAAGVLHHLK
ETFTHTPSYDMSPAMLSVLVKMMLAQAQENVFEKICLPGIRNEFFVLVKVAQEAAKVGEVYRQLHTAMSQAPVKENIPYSWASLVCVKAHHYAALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDHMP
EGLTPLATLKSGHQRRQLGKSHLRRAVAHHEESVREASLCKKLRNIEVLQDVLSVAHERSRLKYAQHQDDDDLLNLIDAPDIISKTEQEVEIILPQFSKVTATDFFQKLGPLSVFSANKRWTPPRSIHFT
AEEGDLGFTLRGNSPVQVHFLDPHCSAALAGAKEGDYIVSIQDVDCKWLTVSEVMKLLKACGRDGVEMKVVSLLDFTSSMHNKCATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTDKNRV
KSASTLCLPSVGVARPQVKKKLPSPFSLLNSDSSLY
Subcellular Location
Description
Show
Cytoplasm, perinuclear region {
By Similarity
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
Show
Cellular Component
Cytosol
(
GO:0005829
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
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Biology & Function
Description
Hide
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). {
By Similarity
}.
Assigned Ontology terms
Show
Biological Process
Negative Regulation Of Stress Fiber Assembly
(
GO:0051497
)
Signal Transduction
(
GO:0007165
)
Molecular Function
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Cross-References
Database
Links
UNIPROT
Q8HXG3
Pfam
PF03097
PF02185
PROSITE
PS51180
PS50106
PS51860
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory