NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Serine/threonine-protein kinase N3 - Mus musculus - NucEnvDB

Serine/threonine-protein kinase N3 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Serine/threonine-protein kinase N3
Accession Code	Q8K045
Gene	Pkn3
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 878)
MEHRKPGTGQRAPKDEKEMVRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPASAEPVTSEPQPRAEQSRARLSEALHRQLQVELKVKQGAENMIHTCASGTPK ERKLLAAAQQMLKDSQLKVALLRMKISSLESSGSPEPGPDLLAEELQHRLRVEAAVAAGAKNVVKLLGGQRMQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTQELWMAMLGNPQP LGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMAVLAGSPSESWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISLDRARELEIGVHWRDWRQLCGVAFLKLEDFLDNACH QLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRCIFSKRRGRDFMRASQMNLSMAAWGRLVMSLLPPCSSPNTASPPKGRPSTAVCGTPSAASPSNFLPMKTLSKEDTKPPPKPPRLYLQEPAPGTPCTK RPHMDPRPAVVPALAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPEPQA CFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQ KLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLES

Subcellular Location

Description
Nucleus {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Note=Nuclear and perinuclear Golgi region. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Contributes to invasiveness in malignant prostate cancer. {Experimental EvidencePubMed:15282551}.
Assigned Ontology terms

Biological Process	Epithelial Cell Migration (GO:0010631) Intracellular Signal Transduction (GO:0035556) Peptidyl-Serine Phosphorylation (GO:0018105)
Molecular Function	ATP Binding (GO:0005524) Calcium-Dependent Protein Kinase C Activity (GO:0004698) Protein Serine Kinase Activity (GO:0106310) Protein Serine/Threonine Kinase Activity (GO:0004674) Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	Q8K045
Pfam	PF02185 PF00069 PF00433
PROSITE	PS51285 PS00107 PS50011 PS00108 PS51860

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