National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Thiosulfate:glutathione sulfurtransferase |
| Accession Code | Q8NFU3 |
| Gene | TSTD1 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 115) |
Structure Viewer (PDB: 6BEV) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
|---|---|
| Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). {Experimental EvidencePubMed:24981631}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q8NFU3 Q5SY48 Q5SY49 Q5SY50 Q5SY51 Q8NFU2 Q9BV22 |
| PDB | 6BEV |
| Pfam | PF00581 |
| PROSITE | PS50206 |
| OMIM | 616041 |
| DisGeNET | 100131187 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory