National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
| Accession Code | Q8QZV1 |
| Gene | Pde9a |
| Organism | Rattus norvegicus | Norway rat (Taxonomy: 10116) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 534) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (By similarity). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:18674549, PubMed:22070409, PubMed:22328573). {By SimilarityUniProtKB:O76083, Experimental EvidencePubMed:18674549, Experimental EvidencePubMed:22070409, Experimental EvidencePubMed:22328573}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory