National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | SUN domain-containing protein 5 |
| Accession Code | Q8TC36 |
| Gene | SUN5 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 379) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Inner Membrane | SL-0179 | The inner membrane of the nucleus is the membrane which separates the nuclear matrix from the intermembrane space. In mammals, the inner nuclear membrane is associated with heterochromatin and the nuclear lamina. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. {Curator InferencePubMed:28541472, Curator InferencePubMed:28945193}. | Assigned Ontology terms |
Description |
|
|---|---|
| Spermatogenic failure 16 (SPGF16) [MIM:617187]: An infertility disorder caused by spermatogenesis defects and characterized by abnormally shaped spermatozoa in the semen of affected individuals. Most spermatozoa are made up of headless tails, while a small proportion has an abnormal head-tail junction. A few spermatozoa are made up of tailless heads. {Experimental EvidencePubMed:27640305, Experimental EvidencePubMed:28541472, Experimental EvidencePubMed:28945193, Experimental EvidencePubMed:29298896}. Note=The disease is caused by variants affecting the gene represented in this entry. | Database Associations |
| OMIM | 613942 617187 |
| DisGeNET | 140732 |
Interactions with Nuclear Envelope proteins (1 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q8TC36 A6NJ82 Q5T9R0 |
| Pfam | PF07738 |
| PROSITE | PS51469 |
| OMIM | 613942 617187 |
| DisGeNET | 140732 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory