NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein NDRG2 - Rattus norvegicus - NucEnvDB

Protein NDRG2 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Protein NDRG2
Accession Code	Q8VBU2
Gene	Ndrg2
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 371)
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSQDQLADMIPC ILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLV VGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC

Subcellular Location

Description
Cytoplasm {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Glutamatergic Synapse (GO:0098978) Growth Cone (GO:0030426) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation. {By Similarity, Experimental EvidencePubMed:16039777}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Negative Regulation Of Cytokine Production (GO:0001818) Negative Regulation Of ERK1 And ERK2 Cascade (GO:0070373) Negative Regulation Of Smooth Muscle Cell Proliferation (GO:0048662) Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation (GO:1904706) Nervous System Development (GO:0007399) Postsynapse Organization (GO:0099173) Regulation Of Platelet-Derived Growth Factor Production (GO:0090361) Regulation Of Vascular Endothelial Growth Factor Production (GO:0010574) Signal Transduction (GO:0007165) Vascular Associated Smooth Muscle Cell Proliferation (GO:1990874) Wnt Signaling Pathway (GO:0016055)
Molecular Function

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P19332	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	EBI-26374040	0.35
Q5XIE8	Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]	EBI-26440627	0.35

Cross-References

Database	Links
UNIPROT	Q8VBU2 Q8VBW2 Q8VI00 Q8VI01
Pfam	PF03096

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