NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

UBX domain-containing protein 4 - Mus musculus - NucEnvDB

UBX domain-containing protein 4 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	UBX domain-containing protein 4
Accession Code	Q8VCH8
Gene	Ubxn4
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 506)
MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSIQMAASWEDEKVTQASSNNFVAIKIDTKSEACLQFSQIYPVVCVPSS FFIGDSGIPLEVIAGSVSADELVTRIHKVQQMHSSKGEASVTNDNQSESSVSTPSASFEPDVCENPESKNTELCETPATS DIKSDTATGGECTGHDSHSQEPHGCSNQRPAEDLTVRVERLTKKLEERREEKRKEEAQREIKKEIERRKTGKEMLDYKRK QEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLTKQAGTEVKRESTARDRSTIARI QFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATS IVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRMLEKRGEDFKKEG KIYRLRTQDDGEDENNTWNGNSTQQM

Structure Viewer (PDB: 2DZK)

Subcellular Location

Description
Endoplasmic reticulum membrane {By SimilarityUniProtKB:Q92575}; Peripheral membrane protein {By SimilarityUniProtKB:Q92575}. Nucleus envelope {By SimilarityUniProtKB:Q92575}. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. {By SimilarityUniProtKB:Q92575}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q92575}
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Nuclear Envelope (GO:0005635)

Biology & Function

Description
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. {By SimilarityUniProtKB:Q92575}.
Assigned Ontology terms

Biological Process	Response To Unfolded Protein (GO:0006986) Ubiquitin-Dependent ERAD Pathway (GO:0030433)
Molecular Function

Cross-References

Database	Links
UNIPROT	Q8VCH8 Q3UGR4 Q8BW17
PDB	2DZK
Pfam	PF00789
PROSITE	PS50033

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