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NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Membrane protein MLC1 - Mus musculus - NucEnvDB
Membrane protein MLC1 (
Mus musculus
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Interactions
Cross-References
General Information
Protein Information
Protein Name
Membrane protein MLC1
Accession Code
Q8VHK5
Gene
Mlc1
Organism
Mus musculus
| House mouse (Taxonomy:
10090
)
Part of Reference Proteome?
Yes
Sequence (Length: 382)
Show
MTREGQFREELGYDRMPTLERGRQDAGRQDPGSYTPDSKPKDLQLSKRLPPCFSYKTWVFSVLMGSCLLVTSGFSLYLGNVFPSEMDYLRCAAGSCIPSAIVSFAVGRRNVSAIPNFQILFVSTFAVTTT
CLIWFGCKLILNPSAININFNLILLLLLELLMAATVIISARSSEEPCKKKKGSISDGSNILDEVTFPARVLKSYSVVEVIAGVSAVLGGVIALNVEEAVSGPHLSVTFFWILVACFPSAIASHVTAECPS
KCLVEVLIAISSLTSPLLFTASGYLSFSVMRVVEIFKDYPPAIKSYDVLLLLLLLLLLLQGGLNTGTAIQCVSFKVSARLQAASWDPQSCPQERPAGEVVRGPLKEFDKEKAWRAVVVQMAQ
Subcellular Location
Description
Show
Membrane {
Curator Inference
}; Multi-pass membrane protein {
Curator Inference
}. Cell membrane {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Transmembrane
UniProt
Sequence Analysis {ECO:0000255}
Assigned Ontology terms
Show
Cellular Component
Apical Plasma Membrane
(
GO:0016324
)
Astrocyte End-Foot
(
GO:0097450
)
Basolateral Plasma Membrane
(
GO:0016323
)
Caveola
(
GO:0005901
)
Cell-Cell Junction
(
GO:0005911
)
Cytoplasm
(
GO:0005737
)
Cytoplasmic Vesicle
(
GO:0031410
)
Cytosol
(
GO:0005829
)
Early Endosome
(
GO:0005769
)
Endoplasmic Reticulum
(
GO:0005783
)
Endosome
(
GO:0005768
)
Lysosome
(
GO:0005764
)
Membrane Raft
(
GO:0045121
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
Plasma Membrane
(
GO:0005886
)
Recycling Endosome
(
GO:0055037
)
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Biology & Function
Description
Hide
Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. {
By Similarity
}.
Assigned Ontology terms
Show
Biological Process
Caveolin-Mediated Endocytosis
(
GO:0072584
)
Cellular Response To Cholesterol
(
GO:0071397
)
Ion Transport
(
GO:0006811
)
Positive Regulation Of Intracellular Transport
(
GO:0032388
)
Protein Transport
(
GO:0015031
)
Regulation Of Response To Osmotic Stress
(
GO:0047484
)
Vesicle-Mediated Transport
(
GO:0016192
)
Molecular Function
Identical Protein Binding
(
GO:0042802
)
Protein-Containing Complex Binding
(
GO:0044877
)
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Protein-Protein Interactions
Interactions with other proteins (1 interactors)
Show
Partner (UniProt)
IntAct
Confidence score
Q8BIZ1
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
EBI-26595802
0.35
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Cross-References
Database
Links
UNIPROT
Q8VHK5
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory