NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Alpha-actinin-4 - Gallus gallus - NucEnvDB

Alpha-actinin-4 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Alpha-actinin-4
Accession Code	Q90734
Gene	ACTN4
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 904)
MVDYHSAGQPYPYGGNGPGPNGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVNVVSIGAEEIVDG NAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHA FSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRSPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINTGWQHLEQAEKGY EEWLLNEIRRLEPLDHLAEKFRQKASIHEAWTEGKEAMLKQKDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDVLGSLTHSRREALEKTEKQLETID ELHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLIAAHDQFKATLPDADREREAILGIQREAQRIADLHSIKLSGNNPYTSVTPQVINSKWERVQQLVPTRDRALQDEQSRQQCNERLRRQFAGQ ANIVGPWMQTKMEEIGRISIEMHGTLEDQLQHLKHYEQSIVDYKPNLELLEHEHQLVEEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHCGALGP EEFKACLISLGYDVENDRQGDAEFNRIMSLVDPNGSGSVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNYITAEELRRELPPEQAEYCIARMAPYRGPDAAPGALDYKSFSTALYGESDL

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:O43707}. Cytoplasm {By SimilarityUniProtKB:O43707}. Cell junction {ECO:0000250\|UniProtKB:P57780}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:P57780}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cell Junction (GO:0030054) Cell Projection (GO:0042995) Cortical Actin Cytoskeleton (GO:0030864) Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Stress Fiber (GO:0001725) Z Disc (GO:0030018)

Biology & Function

Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors. {By SimilarityUniProtKB:O43707}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Muscle Cell Development (GO:0055001) Peroxisome Proliferator Activated Receptor Signaling Pathway (GO:0035357) Protein Transport (GO:0015031) Regulation Of Nucleic Acid-Templated Transcription (GO:1903506) Retinoic Acid Receptor Signaling Pathway (GO:0048384)
Molecular Function	Actin Filament Binding (GO:0051015) Calcium Ion Binding (GO:0005509) Nuclear Receptor Coactivator Activity (GO:0030374)

Cross-References

Database	Links
UNIPROT	Q90734
Pfam	PF00307 PF08726 PF00435
PROSITE	PS00019 PS00020 PS50021 PS50222

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