[Isoform 1]: Nucleus, nuclear pore complex {By
SimilarityUniProtKB:Q9HC62}. Nucleus membrane {By
SimilarityUniProtKB:Q9HC62}; Peripheral membrane protein {By
SimilarityUniProtKB:Q9HC62}; Nucleoplasmic side {By
SimilarityUniProtKB:Q9HC62}. Note=Shuttles between cytoplasm and nucleus. {By
SimilarityUniProtKB:Q9HC62}. [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11489887}. Cytoplasmic vesicle {ECO:0000269|PubMed:11489887}. Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin. {ECO:0000269|PubMed:11489887}. [Isoform 3]: Nucleus, PML body {ECO:0000269|PubMed:12419228}.
The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11489887, PubMed:20194620). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:11489887, PubMed:20194620, PubMed:27637147). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:11489887). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (PubMed:27637147). {By
SimilarityUniProtKB:Q9HC62, Experimental EvidencePubMed:11489887, Experimental EvidencePubMed:20194620, Experimental EvidencePubMed:27637147}. [Isoform 3]: Activates transcription. {Experimental EvidencePubMed:12419228}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory