NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Defective in germ line development protein 3 - Caenorhabditis elegans - NucEnvDB

Defective in germ line development protein 3 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Defective in germ line development protein 3
Accession Code	Q95ZK7
Gene	gld
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 969)
MGEQSHEKDHDEAHSYNPFVRSAVEYDADTRLQMAENAASARKLFVSSALKDIIVNPENFYHDFQQSAQMAEDANQRRQV SYNTKREAHIHQLKAQGLPLPSNIPMIEINPTRVTLNMEFESQYYSLMTSDNGDHENVASIMAETNTLIQLPDRSVGGTT PDPFAQQVTITGYFGDVDRARMLMRRNCHFTVFMALSKMKMPLHELQAHVRQNPIQNVEMSFVDAPEKNGIVTTYLRITA REKNQHELIEAAKRLNEILFRESPAPENNFTLHFTLSTYYVDQVLGSSSTAQLMPVIERETTTIISYPCYNNRNETRGNI YEIKVVGNIDNVLKARRYIMDLLPISMCFNIKNTDMAEPSRVSDRNIHMIIDESGIILKMTPSVYEPADLLSGEVPLNCA SLRSKEFNIKKLYTAYQKVLSKKFDFIAPQPNDYDNSIWHHSLPANFLKNFNMPCRGELSDGSNGRRHRSSSIASSRSKH SYMSKGKQFSESSGGPSRSHTRVSSFSENSSTVPIMQFPTPHFAPPMLTPHHHMLKYVYLQQHQQAQTFLKGAAGLHPGT HIMFPPPIIVDGSFVSALPFADPVVFDGFPYVHGLFPVNEAEQHRNHRESSPSLRSTQEIRKPSRNMGNRPSSSTGSYYP STTPRQRVYEQVREDDLRSHIGSRRTSVNGDDQNVESMHDQGYERQYPRQHQRLQKDDQQRWKTGSRGDIHSSRTINVHR DVRNSNEYDFHVGNSGPAKRSPSLEQVQLQMTHHLKLKSNDVDLDHEKLYMHESPHNDSDTTVSASGFGNDLMDGDFVQR FLSNANINESGRRPRTVSCFTEKDGQSARYIDSDGAYSVVDHASTHQSRSYDSFRKVGDNGVTKTILEPRARVEKDYGKI SLEHKTKYSNEYGDEEKSAENDTSSLGSRQYRIDPMKLIASVRESSEQLPRIHERQFSDVLNEKEKEIADKSIESTVTQD LSLDETSTY

Structure Viewer (PDB: 4ZRL)

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:12431376, Experimental EvidencePubMed:19461891}. Cytoplasmic granule {Experimental EvidencePubMed:12431376, Experimental EvidencePubMed:19461891}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:12431376, Experimental EvidencePubMed:19461891}. Note=Localizes to P granules. Found also in particles near but not coincident with P granules. {Experimental EvidencePubMed:12431376, Experimental EvidencePubMed:19461891}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) P Granule (GO:0043186) Perinuclear Region Of Cytoplasm (GO:0048471) RNA Polymerase Complex (GO:0030880) RNA-Directed RNA Polymerase Complex (GO:0031379)

Biology & Function

Description
Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis. {Experimental EvidencePubMed:12431376, Experimental EvidencePubMed:15454534, Experimental EvidencePubMed:19461891}.
Assigned Ontology terms

Biological Process	Embryo Development Ending In Birth Or Egg Hatching (GO:0009792) Germ-Line Sex Determination (GO:0018992) Germ-Line Stem Cell Division (GO:0042078) Masculinization Of Hermaphroditic Germ-Line (GO:0042006) Meiotic Cell Cycle (GO:0051321) Mitotic Cytokinesis (GO:0000281) MRNA Polyadenylation (GO:0006378) MRNA Processing (GO:0006397) Negative Regulation Of Binding (GO:0051100) Nematode Larval Development (GO:0002119) Nuclear Division (GO:0000280) Positive Regulation Of Gene Expression (GO:0010628) Positive Regulation Of Meiosis I (GO:0060903) Positive Regulation Of Meiotic Nuclear Division (GO:0045836) Positive Regulation Of Mitotic Nuclear Division (GO:0045840) Positive Regulation Of Multicellular Organism Growth (GO:0040018) Regulation Of Translation (GO:0006417) RNA Polyadenylation (GO:0043631) Spermatogenesis (GO:0007283) Vulval Development (GO:0040025)
Molecular Function	Polynucleotide Adenylyltransferase Activator Activity (GO:1990749) Protein Domain Specific Binding (GO:0019904) RNA Binding (GO:0003723)

Protein-Protein Interactions

Interactions with other proteins (11 interactors)

Partner (UniProt)		IntAct	Confidence score
O17670	Eyes absent homolog 1 (EC 3.1.3.48)	EBI-334985	0.00
G5EDS1	Paired box protein 6 homolog (Homeobox and paired domain-containing protein vab-3) (Protein male abnormal 18) (Variable abnormal morphology protein 3)	EBI-336095	0.00
G5EFL5	ALP/Enigma encoding	EBI-341465	0.00
Q95QA6	Protein pat-12 (Paralyzed arrest at two-fold 12 protein)	EBI-341819	0.00
O17087	Poly(A) RNA polymerase gld-2 (EC 2.7.7.19) (Defective in germ line development protein 2)	EBI-3891184	0.51
O76572	EPHeXin (Eph-interacting GEF) homolog	EBI-6535647	0.37
Q10666	Protein pop-1 (Posterior pharynx defect protein 1)	EBI-11467458	0.37
Q10953	Armadillo repeat-containing protein wrm-1 (Worm armadillo protein 1)	EBI-11467642	0.37
Q8I4M5	Germline survival defective-1	EBI-14989511	0.63
Q09312	Fem-3 mRNA-binding factor 2	EBI-14989599	0.37
Q9N5M6	Fem-3 mRNA-binding factor 1	EBI-14989696	0.54

Cross-References

Database	Links
UNIPROT	Q95ZK7 Q95ZK6
PDB	3N89 4ZRL
Pfam	PF17905

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK