NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Tumor necrosis factor receptor superfamily member 19L - Homo sapiens - NucEnvDB

Tumor necrosis factor receptor superfamily member 19L (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Tumor necrosis factor receptor superfamily member 19L
Accession Code	Q969Z4
Gene	RELT
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 430)
MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQGTLCRPCPPGTFSAAWGSSPCQPHARCSLWRRLEAQVGMATRDTLCGDCWPGWFGPWGVPRVPCQPCSWAPLGTHGCDEWGRRARR GVEVAAGASSGGETRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRP VSKLPPAPPNVPHICPHRHHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGAKAGRQGEITILSVGRFRVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPP EQQALLGSGGSRTKWLKPPAENKAEENRYVVRLSESNLVI

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:16389068}; Single-pass type I membrane protein {Experimental EvidencePubMed:16389068}. Cytoplasm {Experimental EvidencePubMed:16389068}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:22052202}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). {Experimental EvidencePubMed:16530727, Experimental EvidencePubMed:19969290, Experimental EvidencePubMed:28688764, Experimental EvidencePubMed:30506946}.
Assigned Ontology terms

Biological Process	Amelogenesis (GO:0097186) Apoptotic Process (GO:0006915)
Molecular Function

Disease associations

Description
Amelogenesis imperfecta 3C (AI3C) [MIM:618386]: An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides. {Experimental EvidencePubMed:30506946}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	611211 618386
DisGeNET	84957

Protein-Protein Interactions

Interactions with other proteins (13 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9H8J5	MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein)	EBI-21537025	0.35
P04201	Proto-oncogene Mas	EBI-21538834	0.35
Q96GQ5	RUS family member 1	EBI-21549001	0.35
Q8NHX9	Two pore channel protein 2 (Two pore calcium channel protein 2)	EBI-21578009	0.35
Q9UEW8	STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)	EBI-21648169	0.35
Q6WKZ4	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)	EBI-21648169	0.35
O95747	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)	EBI-21648169	0.35
O00154	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)	EBI-21648169	0.35
P37173	TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)	EBI-21668347	0.35
A8MVW5	HEPACAM family member 2 (Mitotic kinetics regulator)	EBI-21700110	0.35
P24394	Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]	EBI-21800565	0.35
Q8NC24	RELT-like protein 2	EBI-21817939	0.35
Q8NFM7	Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef)	EBI-21858188	0.35

Cross-References

Database	Links
UNIPROT	Q969Z4 Q86V34 Q96JU1 Q9BUX7
Pfam	PF12606
OMIM	611211 618386
DisGeNET	84957

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