National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Lysophospholipase D GDPD3 |
| Accession Code | Q99LY2 |
| Gene | Gdpd3 |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 330) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25528375, PubMed:27637550). Shows a preference for 1-O-alkyl- sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso- PC) and N-acylethanolamine lysophospholipids (PubMed:25528375). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (PubMed:25528375). {Experimental EvidencePubMed:25528375, Experimental EvidencePubMed:27637550}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory