Protein Information |
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Protein Name | Lecithin retinol acyltransferase |
Accession Code | Q9BGL2 |
Gene | LRAT |
Organism | Bos taurus | Cattle (Taxonomy: 9913) |
Part of Reference Proteome? | Yes |
Sequence (Length: 230) |
Description |
Position in the Nuclear Envelope |
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Location | Location ID | Description |
Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
Topology | Source | Annotation Type |
Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
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Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938, PubMed:2722792). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). {By SimilarityUniProtKB:Q9JI60, Experimental EvidencePubMed:2722792, Experimental EvidencePubMed:9920938, Curator InferencePubMed:9920938}. | Assigned Ontology terms |