NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Plasminogen activator inhibitor 1 RNA-binding protein - Mus musculus - NucEnvDB

Plasminogen activator inhibitor 1 RNA-binding protein (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Plasminogen activator inhibitor 1 RNA-binding protein
Accession Code	Q9CY58
Gene	Serbp1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 407)
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKN PLPPSVGVADKKEETQPPVALKKEGIRRVGRRPDQQLQGDGKLIDRRAERRPPRERRFEKPLEEKGEGGEFSVDRPIIER PIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQK QISYNCSDLDQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKK GFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDP EAFPALA

Structure Viewer (PDB: 7LS1)

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q8NC51}. Nucleus {By SimilarityUniProtKB:Q8NC51}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q8NC51}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. {By SimilarityUniProtKB:Q8NC51}.
Assigned Ontology terms

Biological Process	PML Body Organization (GO:0030578) Regulation Of Apoptotic Process (GO:0042981)
Molecular Function	MRNA 3'-UTR Binding (GO:0003730) Ribosome Binding (GO:0043022) RNA Binding (GO:0003723) SUMO Binding (GO:0032183)

Protein-Protein Interactions

Interactions with other proteins (5 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9CQT7	Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2)	EBI-7770477	0.37
Q9JIF0	Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1)	EBI-6393214	0.35
P14094	Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)	EBI-20566937	0.35
Q6UWE0	E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)	EBI-22050272	0.35
D0ZIB5	Secreted effector kinase SteC (EC 2.7.-.-) (Salmonella translocated effector C)	EBI-27035217	0.46

Cross-References

Database	Links
UNIPROT	Q9CY58 Q8BHS2 Q8BHU0 Q91WP3 Q9CSN0 Q9DBY6
PDB	7LS1 7LS2
Pfam	PF04774 PF16174

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