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A database of Nuclear Envelope Proteins and their Interactions
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Synapse-associated protein 1 - Mus musculus - NucEnvDB
Synapse-associated protein 1 (
Mus musculus
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Interactions
Cross-References
General Information
Protein Information
Protein Name
Synapse-associated protein 1
Accession Code
Q9D5V6
Gene
Syap1
Organism
Mus musculus
| House mouse (Taxonomy:
10090
)
Part of Reference Proteome?
Yes
Sequence (Length: 365)
Show
MFGGLSSWLGLKPPEGAAAEGEEPPSRDGDKLSAGAAPSEESPERPVEPTEEQQQQPPTEDPQFLHQAKGLGNYLYNFASAATKKITESVTETAQTIKKSVEEGKIDDILDKTILGDFQKEQKKFVEEQN
TKKSEAAVPPWVESHDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRISLIKQSAQLTALAAQQQASGKEEKSSNRDDNLPLTEAVRP
KTPPVVIKSQLKSQEDEEEISTSPGVSEFVSDAFDTCSLNQEDLRKEMEQLVLDKKQEEATALEEDSTDWEKELQQELQEYEVVAESEKRDENWDKEIEKMLQES
Subcellular Location
Description
Show
Cytoplasm, perinuclear region {
Experimental Evidence
PubMed:27344443
}. Golgi apparatus {
Experimental Evidence
PubMed:27344443
}. Perikaryon {
Experimental Evidence
PubMed:27344443
}. Cell projection, axon {
Experimental Evidence
PubMed:27344443
}. Cell projection, dendrite {
Experimental Evidence
PubMed:27344443
}. Cell projection, growth cone {
Experimental Evidence
PubMed:27344443
}. Presynaptic cell membrane {
Experimental Evidence
PubMed:27344443
}. Postsynaptic cell membrane {
Experimental Evidence
PubMed:27344443
}. Membrane {ECO:0000250|UniProtKB:Q96A49}. Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (PubMed:27344443). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q96A49,
Experimental Evidence
PubMed:27344443
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
Show
Cellular Component
Anchoring Junction
(
GO:0070161
)
Axon
(
GO:0030424
)
Cytoplasm
(
GO:0005737
)
Cytosol
(
GO:0005829
)
Dendrite
(
GO:0030425
)
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
(
GO:0031234
)
Golgi Apparatus
(
GO:0005794
)
Growth Cone
(
GO:0030426
)
Nucleoplasm
(
GO:0005654
)
Nucleus
(
GO:0005634
)
Perikaryon
(
GO:0043204
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
Postsynaptic Membrane
(
GO:0045211
)
Presynaptic Membrane
(
GO:0042734
)
Synapse
(
GO:0045202
)
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Biology & Function
Description
Hide
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {
Experimental Evidence
PubMed:23300339
}.
Assigned Ontology terms
Show
Biological Process
Cell Differentiation
(
GO:0030154
)
Cellular Response To Epidermal Growth Factor Stimulus
(
GO:0071364
)
Cellular Response To Insulin Stimulus
(
GO:0032869
)
Cellular Response To Insulin-Like Growth Factor Stimulus
(
GO:1990314
)
Cellular Response To Platelet-Derived Growth Factor Stimulus
(
GO:0036120
)
Positive Regulation Of Fat Cell Differentiation
(
GO:0045600
)
Positive Regulation Of Protein Serine/Threonine Kinase Activity
(
GO:0071902
)
Regulation Of Short-Term Neuronal Synaptic Plasticity
(
GO:0048172
)
TORC2 Signaling
(
GO:0038203
)
Molecular Function
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Protein-Protein Interactions
Interactions with other proteins (1 interactors)
Show
Partner (UniProt)
IntAct
Confidence score
P97493
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
EBI-26499997
0.35
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Cross-References
Database
Links
UNIPROT
Q9D5V6
Q3UI67
Q9D870
Pfam
PF03909
PROSITE
PS50858
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory