The host perinuclear region is the host cytoplasmic region just around the host nucleus. Note: This location is defined for viral proteins that appear in the perinuclear region of infected host cells
RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs (Probable). These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (PubMed:27300328). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (PubMed:23576516). {Experimental EvidencePubMed:23576516, Experimental EvidencePubMed:27300328, Curator InferencePubMed:27300328}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory