NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

LIM domain-binding protein 3 - Mus musculus - NucEnvDB

LIM domain-binding protein 3 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	LIM domain-binding protein 3
Accession Code	Q9JKS4
Gene	Ldb3
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 723)
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTL QKSKRPIPISTTAPPIQSPLPVIPHQKDPALDTNGSLATPSPSPEARASPGALEFGDTFSSSFSQTSVCSPLMEASGPVL PLGSPVAKASSEGAQGSVSPKVLPGPSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGAGLLGGSLPVKDLAVDSAS PVYQAVIKTQSKPEDEADEWARRSSNLQSRSFRILAQMTGTEYMQDPDEEALRRSSTPIEHAPVCTSQATSPLLPASAQS PAAASPIAASPTLATAAATHAAAASAAGPAASPVENPRPQASAYSPAAAASPAPSAHTSYSEGPAAPAPKPRVVTTASIR PSVYQPVPASSYSPSPGANYSPTPYTPSPAPAYTPSPAPTYTPSPAPTYSPSPAPAYTPSPAPNYTPTPSAAYSGGPSES ASRPPWVTDDSFSQKFAPGKSTTTVSKQTLPRGAPAYNPTGPQVTPLARGTFQRAERFPASSRTPLCGHCNNVIRGPFLV AMGRSWHPEEFNCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPICAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFG NSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDKPLCKKHAHA INV

Structure Viewer (PDB: 1WJL)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:10391924}. Cell projection, pseudopodium {Experimental EvidencePubMed:10391924}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:10391924}. Cytoplasm, myofibril, sarcomere, Z line {Experimental EvidencePubMed:10391924}. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Adherens Junction (GO:0005912) Cytoskeleton (GO:0005856) Filamentous Actin (GO:0031941) Perinuclear Region Of Cytoplasm (GO:0048471) Pseudopodium (GO:0031143) Stress Fiber (GO:0001725) Z Disc (GO:0030018)

Biology & Function

Description
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {Curator InferencePubMed:10391924}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Heart Development (GO:0007507) Muscle Structure Development (GO:0061061) Sarcomere Organization (GO:0045214)
Molecular Function	Actin Binding (GO:0003779) Cytoskeletal Protein Binding (GO:0008092) Enzyme Binding (GO:0019899) Metal Ion Binding (GO:0046872) Muscle Alpha-Actinin Binding (GO:0051371) Protein C-Terminus Binding (GO:0008022) Protein Kinase C Binding (GO:0005080)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (3 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P28867	Protein kinase C delta type catalytic subunit	EBI-7048669	0.40
P16054	Protein kinase C epsilon type	EBI-299155	0.56
P63318	Protein kinase C gamma type	EBI-7048648	0.40
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9JI91	Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)	EBI-7048448	0.57
P68404	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	EBI-7048489	0.49
P20444	Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)	EBI-7048605	0.40
Q02956	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	EBI-7048713	0.40
P51637	Caveolin-3 (M-caveolin)	EBI-20565496	0.35
A2AKD7	Alpha-1-syntrophin	EBI-20566393	0.35

Cross-References

Database	Links
UNIPROT	Q9JKS4 B2RSB0 B7ZNT6 Q6A038 Q811P2 Q811P3 Q811P4 Q811P5 Q9D130 Q9JKS3 Q9R0Z1 Q9WVH1 Q9WVH2
PDB	1WJL
Pfam	PF15936 PF00412 PF00595
PROSITE	PS00478 PS50023 PS50106

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