NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Interferon-induced GTP-binding protein Mx1 - Canis lupus familiaris - NucEnvDB

Interferon-induced GTP-binding protein Mx1 (Canis lupus familiaris)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Interferon-induced GTP-binding protein Mx1
Accession Code	Q9N0Y3
Gene	MX1
Organism	Canis lupus familiaris \| Dog (Taxonomy: 9615)
Part of Reference Proteome?	Yes
Sequence (Length: 657)
MVNSQGKITDSNPVPNHVLLNGLTDKAEKNQGIGNSLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLINEDEWRGKVSYQDTEMEIS DPSEVEVEINKAQDAIAGEGQGISHELISLEVSSPHVPDLTLIDLPGITRVAVGNQPADIGRQTKQLIRKYILKQETINLVVVPCNVDIATTEALSMAQEVDPDGDRTIGILTKPDLVDRGTEGKVVDVA QNLVCHLKKGYMIVKCRGQQDIQDQVSLAEALQKEKDFFEDHPHFRVLLEEGRATVPNLAEKLTSELITHICKTLPLLENQIKENHEKITEELQKYGSDVPEDEHEKMFFLIDKLNAFNQDISSLIQGEE SVGEDESRLFTKIRNEFHKWSAVIEKKFQRGYKAIYKQMEKFENRYRGRELPGFVNYKTFEIIIKQQIKELEEPAVDMLHTITDMVQVAFGDISKANFDEFFNLYRTTKSKIEDIKFELEKEAEKSIRLH FQMEQIVYCQDHVYQRALQRVREKDSDEEKKKKTSSMSHDEVSSVNISLSEILEHLLAYRQEATNRISSHIPLIIQYFILQVYGQKLQNGMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLAQARR RLAKFPG

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:15767791}. Endoplasmic reticulum membrane {By Similarity}; Peripheral membrane protein {By Similarity}; Cytoplasmic side {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Note=Binds preferentially to negatively charged phospholipids. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum Membrane (GO:0005789) Exocytic Vesicle (GO:0070382) Membrane (GO:0016020) Microtubule (GO:0005874) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Interferon-induced dynamin-like GTPase with antiviral activity. {By Similarity}.
Assigned Ontology terms

Biological Process	Defense Response To Virus (GO:0051607) Innate Immune Response (GO:0045087)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Microtubule Binding (GO:0008017)

Cross-References

Database	Links
UNIPROT	Q9N0Y3
Pfam	PF01031 PF00350 PF02212
PROSITE	PS00410 PS51718 PS51388

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