NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Translin-associated protein X - Mus musculus - NucEnvDB

Translin-associated protein X (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Translin-associated protein X
Accession Code	Q9QZE7
Gene	Tsnax
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 290)
MNGKEGPGGFRKRKHDTFPHNQRREGKDASLSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEEILTESESKLDGVRQKILQVAQELSGEDMHQFHRAVTTGLQEYVEA VSFQHFIKTRSLISMEEINKQLTFTAEDSGKESKTPPAEGQEKQLVTWRLKLTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYAL KVRGSEIPKHMLADVFSVKTDMIDQEESIS

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Golgi apparatus {Experimental EvidencePubMed:15314092}. Nucleus {By Similarity}. Note=Expressed in the cytoplasm in the presence of TSN (By similarity). Accumulate in the Golgi complex of mid-late pachytene spermatocytes. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoribonuclease Complex (GO:1902555) Golgi Apparatus (GO:0005794) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) SiRNA Processing (GO:0030422) Spermatogenesis (GO:0007283)
Molecular Function	A2A Adenosine Receptor Binding (GO:0031687) Endoribonuclease Activity (GO:0004521) Metal Ion Binding (GO:0046872) Protein-Containing Complex Binding (GO:0044877) RNA Binding (GO:0003723) Sequence-Specific DNA Binding (GO:0043565) Single-Stranded DNA Binding (GO:0003697)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P30543	Adenosine receptor A2a	EBI-2910466	0.60
Q60613	Adenosine receptor A2a	EBI-2910848	0.27

Cross-References

Database	Links
UNIPROT	Q9QZE7 Q3UJR2
Pfam	PF01997

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