NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Inositol 1,4,5-trisphosphate receptor type 1 - Bos taurus - NucEnvDB

Inositol 1,4,5-trisphosphate receptor type 1 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Inositol 1,4,5-trisphosphate receptor type 1
Accession Code	Q9TU34
Gene	ITPR1
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 2709)
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNK YLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQ HVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRL RHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIF KLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQE LICKAVLNPTNADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWVFWRDSNKEVRSKSVRELAQDAKEGQKEDRDVLGYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPSDLRAS FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGTSKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMA KGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPTATAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGI FGGSEETTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDEAMDGASGENEHKKTEEGNNKSQQHESTSS YNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTMMQEIMRLAHEFLQNFCAGNHPNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIE THGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCY VDPEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNN LFLKSHNLVQKTAMNWRLTARNAARRDSVLPVSRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGE KGEALRQILVNRYYGNIRPSGRRESLTSFGNGPLSPGGPSKPGGGGGGSGSSPMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFY DRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPATQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQSGEGAQAAADKSKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQ NNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKEL VEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGDETLDFYAQPTGPNEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLF NEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTR GYRAMVLDVEFLYHLLXLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILMAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETSLPEASESLASEFLYSDVCRVETGENCSSPAPK EELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHY LCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGLLSELKDQMTDQRKQKQRMGLLGHPPHINVNPQQPA

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:11584008}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasmic vesicle, secretory vesicle membrane {Experimental EvidencePubMed:11584008}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:Q14643}. Note=Endoplasmic reticulum and secretory granules (PubMed:11584008). {Experimental EvidencePubMed:11584008}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Obsolete Integral Component Of Endoplasmic Reticulum Membrane (GO:0030176) Perinuclear Region Of Cytoplasm (GO:0048471) Presynapse (GO:0098793) Rough Endoplasmic Reticulum (GO:0005791) Secretory Granule (GO:0030141) Transport Vesicle Membrane (GO:0030658)

Biology & Function

Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. {By SimilarityUniProtKB:P11881, Experimental EvidencePubMed:11584008}.
Assigned Ontology terms

Biological Process	Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress (GO:0070059) Release Of Sequestered Calcium Ion Into Cytosol (GO:0051209)
Molecular Function	Calcium-Release Channel Activity (GO:0015278) Inositol 1,4,5 Trisphosphate Binding (GO:0070679) Inositol 1,4,5-Trisphosphate-Sensitive Calcium-Release Channel Activity (GO:0005220) Phosphatidylinositol Binding (GO:0035091)

Cross-References

Database	Links
UNIPROT	Q9TU34 Q7M2U0
Pfam	PF08709 PF00520 PF02815 PF08454 PF01365
PROSITE	PS50919

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