NADPH-dependent diflavin oxidoreductase 1 - Homo sapiens

NADPH-dependent diflavin oxidoreductase 1 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	NADPH-dependent diflavin oxidoreductase 1
Accession Code	Q9UHB4
Gene	NDOR1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 597)
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRK NLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPP PGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACL SLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQIL VAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVS EALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA

Structure Viewer (PDB: 4H2D)

Subcellular Location

Description
Cytoplasm, perinuclear region {Sequence AnalysisHAMAP- Rule:MF_03178, Experimental EvidencePubMed:10625700, Experimental EvidencePubMed:12871939}. Note=Concentrated in perinuclear structure. {Sequence AnalysisHAMAP-Rule:MF_03178, Experimental EvidencePubMed:12871939}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Intermediate Filament Cytoskeleton (GO:0045111) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:28648056, PubMed:23596212, PubMed:20802492, PubMed:15900210). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:28648056, PubMed:23596212, PubMed:20802492). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:23596212, PubMed:20802492). It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938). {Sequence AnalysisHAMAP-Rule:MF_03178, Experimental EvidencePubMed:10625700, Experimental EvidencePubMed:12871938, Experimental EvidencePubMed:15900210, Experimental EvidencePubMed:20802492, Experimental EvidencePubMed:23596212, Experimental EvidencePubMed:28648056}.
Assigned Ontology terms

Biological Process	Cell Death (GO:0008219) Cellular Response To Menadione (GO:0036245) Electron Transport Chain (GO:0022900) Iron-Sulfur Cluster Assembly (GO:0016226)
Molecular Function	Electron Transfer Activity (GO:0009055) FAD Binding (GO:0071949) Flavin Adenine Dinucleotide Binding (GO:0050660) FMN Binding (GO:0010181) NADP Binding (GO:0050661) NADPH Binding (GO:0070402) NADPH-Hemoprotein Reductase Activity (GO:0003958) Oxidoreductase Activity (GO:0016491) Oxidoreductase Activity, Acting On Iron-Sulfur Proteins As Donors, NAD Or NADP As Acceptor (GO:0016731) Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor (GO:0016653)

Protein-Protein Interactions

Interactions with other proteins (28 interactors)

Partner (UniProt)		IntAct	Confidence score
Q6FI81	Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)	EBI-10249769	0.84
P15884	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	EBI-10321093	0.67
Q5JR59	Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)	EBI-10321103	0.67
Q5JST6	EF-hand domain-containing family member C2	EBI-10321113	0.56
Q9BT92	Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)	EBI-10321135	0.78
Q9UMX0	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	EBI-24323853	0.56
Q9UHD9	Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)	EBI-24367687	0.56
P25791	Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)	EBI-24528524	0.56
P28072	Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)	EBI-24684590	0.56
Q96N21	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)	EBI-24695401	0.56
Q6NX45	Zinc finger protein 774	EBI-24699274	0.56
Q6ZNG0	Zinc finger protein 620	EBI-24722294	0.56
B2RXF5	Zinc finger and BTB domain-containing protein 42	EBI-24540997	0.56
Q8TAP4	LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)	EBI-23906101	0.56
Q6ZU52	Uncharacterized protein KIAA0408	EBI-25282111	0.56
Q86UT8	Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84)	EBI-25288817	0.56
O95995	Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)	EBI-24394954	0.56
Q08117	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	EBI-24398378	0.56
Q15742	NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)	EBI-24399846	0.56
P14652	Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8)	EBI-24401557	0.56
Q13227	G protein pathway suppressor 2 (GPS-2)	EBI-24459411	0.56
P50221	Homeobox protein MOX-1 (Mesenchyme homeobox 1)	EBI-24471396	0.56
Q8TBB1	E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)	EBI-24591651	0.56
Q9UBE8	Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)	EBI-24799487	0.56
Q53FD0	Zinc finger C2HC domain-containing protein 1C	EBI-25269225	0.56
Q8N5R6	Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)	EBI-22120931	0.37
Q9H3K6	BolA-like protein 2	EBI-27033149	0.40
O76003	Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)	EBI-27033155	0.40

Cross-References

Database	Links
UNIPROT	Q9UHB4 D3YTG6 D3YTH9 Q5VSG4 Q86US9 Q96BC6
PDB	4H2D
Pfam	PF00667 PF00258 PF00175
PROSITE	PS51384 PS50902
OMIM	606073
DisGeNET	27158

NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

NADPH-dependent diflavin oxidoreductase 1 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4H2D)

Subcellular Location

Description

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description

Assigned Ontology terms

Protein-Protein Interactions

Interactions with other proteins (28 interactors)

Cross-References

Database

Links

NADPH-dependent diflavin oxidoreductase 1 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4H2D)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with other proteins (28 interactors)

Cross-References

Database

Links

Description

Description