C-Jun-amino-terminal kinase-interacting protein 3 - Homo sapiens

C-Jun-amino-terminal kinase-interacting protein 3 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	C-Jun-amino-terminal kinase-interacting protein 3
Accession Code	Q9UPT6
Gene	MAPK8IP3
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 1336)
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVEL ELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE YNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQ VTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEG ADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE HPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARR EQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTLTTSKVVIIDANQPGTVVDQF TVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVAT IANGKVNPSQSTEEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLM DLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQ HLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPGPAAPASEVEGQKLR NVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE

Structure Viewer (PDB: 4PXJ)

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q9ESN9}. Golgi apparatus {By SimilarityUniProtKB:Q9ESN9}. Cytoplasmic vesicle {By SimilarityUniProtKB:Q9ESN9}. Cell projection, growth cone {By SimilarityUniProtKB:Q9ESN9}. Cell projection, axon {ECO:0000250\|UniProtKB:E9PSK7}. Cell projection, dendrite {ECO:0000250\|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. {ECO:0000250\|UniProtKB:E9PSK7, By SimilarityUniProtKB:Q9ESN9}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Axon Cytoplasm (GO:1904115) Cell Body (GO:0044297) Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Dendrite (GO:0030425) Golgi Membrane (GO:0000139) Growth Cone (GO:0030426) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {By SimilarityUniProtKB:Q9ESN9, Experimental EvidencePubMed:12189133, Experimental EvidencePubMed:21775604}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Protein Transport (GO:0099641) Axon Development (GO:0061564) Axon Regeneration (GO:0031103) Negative Regulation Of Apoptotic Process (GO:0043066) Positive Regulation Of JNK Cascade (GO:0046330) Protein Stabilization (GO:0050821) Regulation Of JNK Cascade (GO:0046328) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	JUN Kinase Binding (GO:0008432) Kinesin Binding (GO:0019894) MAP-Kinase Scaffold Activity (GO:0005078) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Disease associations

Description
Neurodevelopmental disorder with or without variable brain abnormalities (NEDBA) [MIM:618443]: A disorder characterized by global developmental delay, impaired intellectual development, delayed walking, poor or absent speech, and variable brain anomalies including perisylvian polymicrogyria, cerebral or cerebellar atrophy, and hypoplasia of the corpus callosum. {Experimental EvidencePubMed:30612693, Experimental EvidencePubMed:30945334}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	605431 618443
DisGeNET	23162

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (5 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O60271	C-Jun-amino-terminal kinase-interacting protein 4	EBI-21663692	0.35
O95271	Poly [ADP-ribose] polymerase tankyrase-1	EBI-21663692	0.35
P61026	Ras-related protein Rab-10	EBI-25437687	0.40
Q06609	DNA repair protein RAD51 homolog 1	EBI-9064650	0.37
Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	EBI-21663692	0.35
Interactions with other proteins (18 interactors)

Partner (UniProt)		IntAct	Confidence score
P49703	ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L)	EBI-733846	0.00
Q9NPQ8	Synembryn-A (Protein Ric-8A)	EBI-735046	0.00
P41182	B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)	EBI-765648	0.35
Q5SW96	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)	EBI-11773591	0.72
O75771	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)	EBI-24283411	0.56
Q9BR01	Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST)	EBI-24292821	0.56
Q86XF7	Zinc finger protein 575	EBI-24446837	0.56
Q07866	Kinesin light chain 1 (KLC 1)	EBI-24450497	0.56
Q9UJW0	Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)	EBI-21663692	0.35
Q9NZ32	Actin-related protein 10 (Actin-related protein 11) (hARP11)	EBI-21663692	0.35
Q9H977	WD repeat-containing protein 54	EBI-21663692	0.35
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)	EBI-21663692	0.35
Q13387	C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)	EBI-21663692	0.35
O00399	Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3)	EBI-21663692	0.35
A6NED2	RCC1 domain-containing protein 1	EBI-21716445	0.35
Q147U7	Single-pass membrane and coiled-coil domain-containing protein 1 (Single-pass membrane protein with coiled-coil domains 1)	EBI-21768421	0.35
P61006	Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)	EBI-25436861	0.40
P51114	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	EBI-26510762	0.37

Cross-References

Database	Links
UNIPROT	Q9UPT6 A2A2B3 A7E2B3 Q96RY4 Q9H4I4 Q9H7P1 Q9NUG0
PDB	4PXJ
Pfam	PF16471 PF09744
PROSITE	PS51776 PS51777
OMIM	605431 618443
DisGeNET	23162

C-Jun-amino-terminal kinase-interacting protein 3 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4PXJ)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Disease associations

Description

Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (5 interactors)

Interactions with other proteins (18 interactors)

Cross-References

Database

Links

Description

Description