NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Rab proteins geranylgeranyltransferase component A - Drosophila melanogaster - NucEnvDB

Rab proteins geranylgeranyltransferase component A (Drosophila melanogaster)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Rab proteins geranylgeranyltransferase component A
Accession Code	Q9V8W3
Gene	Rep
Organism	Drosophila melanogaster (Taxonomy: 7227)
Part of Reference Proteome?	Yes
Sequence (Length: 511)
MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARLDQEVEPHSALRNARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYA EFRAVDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLEYLQAQRVTEKISSCVMQAIAMCGPSTSFEEGMQRTQRFLGSLGRYGNTPFLFPMYGCGELP QCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKNVVSAPGYTPVSKGIELKPHISRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAFLIQLSHYTGACPEGLYIFHLTTPALSE DPASDLAIFTSQLFDQSDAQIIFSSYFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGEDPSALNEHTLPEDLRAQLHDMQQATQEMDIQE

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:10082978}. Cytoplasm, cytoskeleton, spindle pole {Experimental EvidencePubMed:10082978}. Note=Coordinated with the cell cycle, located around nuclei during prophase and telophase. Located to spindle poles during metaphase.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Aster (GO:0005818) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Membrane (GO:0016020) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Rab-Protein Geranylgeranyltransferase Complex (GO:0005968) Spindle Pole (GO:0000922) Synaptic Vesicle (GO:0008021)

Biology & Function

Description
Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Cycle (GO:0007049) Intracellular Protein Transport (GO:0006886) Neurotransmitter Secretion (GO:0007269) Positive Regulation Of Protein Localization To Endoplasmic Reticulum (GO:1905552) Protein Geranylgeranylation (GO:0018344) Small GTPase Mediated Signal Transduction (GO:0007264) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	GDP-Dissociation Inhibitor Activity (GO:0005092) GTPase Activator Activity (GO:0005096)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A0B4K7J4	Glial cell line-derived neurotrophic family receptor-like, isoform E	EBI-249184	0.00
Q9VN77	Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha)	EBI-16092252	0.50
Q9W501	LD45906p (Tempura, isoform A) (Tempura, isoform B)	EBI-16092228	0.50

Cross-References

Database	Links
UNIPROT	Q9V8W3 O97142
Pfam	PF00996

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