The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
Part of the nuclear pore complex (PubMed:14638854). Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad (PubMed:17682050, PubMed:20547758, PubMed:17032737). Protects mbo/Nup88 from proteasomal degradation at the nuclear pore (PubMed:17032737). Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export (PubMed:17032737). Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal- related immunity factor (Dif) and the activation of an immune response (PubMed:17032737). {Experimental EvidencePubMed:14638854, Experimental EvidencePubMed:17032737, Experimental EvidencePubMed:17682050, Experimental EvidencePubMed:20547758}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory