Nucleus, nuclear pore complex {By
SimilarityUniProtKB:Q9NRG9}. Cytoplasm, cytoskeleton, spindle {Experimental EvidencePubMed:26246606}. Note=During mitosis localizes throughout the spindle, is excluded from chromatin, and is enriched on the nuclear envelope remnants that surround the spindle. Present in a ring that surrounds the centrosome in prometaphase and metaphase cells. {Experimental EvidencePubMed:26246606}.
The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory