NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Interferon-inducible double-stranded RNA-dependent protein kinase activator A - Mus musculus - NucEnvDB

Interferon-inducible double-stranded RNA-dependent protein kinase activator A (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Accession Code	Q9WTX2
Gene	Prkra
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 313)
MSHSRHRAEAPPLQREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQVHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGS LQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSLPNTDYIQLLSEIASEQGFNITYLD IEELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Cytoplasm {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) RISC Complex (GO:0016442) RISC-Loading Complex (GO:0070578)

Biology & Function

Description
Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9- p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. {By Similarity, Experimental EvidencePubMed:10336432, Experimental EvidencePubMed:22214662}.
Assigned Ontology terms

Biological Process	Cellular Response To Oxidative Stress (GO:0034599) Ear Development (GO:0043583) Middle Ear Morphogenesis (GO:0042474) MiRNA Processing (GO:0035196) Outer Ear Morphogenesis (GO:0042473) Positive Regulation Of Cell Population Proliferation (GO:0008284) Positive Regulation Of Intrinsic Apoptotic Signaling Pathway (GO:2001244) Pre-MiRNA Processing (GO:0031054) Protein Phosphorylation (GO:0006468) Protein Stabilization (GO:0050821) Regulation Of Production Of Small RNA Involved In Gene Silencing By RNA (GO:0070920) SiRNA Processing (GO:0030422) Skeletal System Morphogenesis (GO:0048705)
Molecular Function	Double-Stranded RNA Binding (GO:0003725) Enzyme Activator Activity (GO:0008047) Enzyme Binding (GO:0019899) Identical Protein Binding (GO:0042802) Pre-MiRNA Binding (GO:0070883) Protein Homodimerization Activity (GO:0042803) Protein Kinase Binding (GO:0019901) SiRNA Binding (GO:0035197)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q6NZM9	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-26472137	0.35

Cross-References

Database	Links
UNIPROT	Q9WTX2 Q9CZB7
Pfam	PF00035 PF16482
PROSITE	PS50137

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