NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Inositol 1,4,5-triphosphate receptor associated 1 - Mus musculus - NucEnvDB

Inositol 1,4,5-triphosphate receptor associated 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Inositol 1,4,5-triphosphate receptor associated 1
Accession Code	Q9WUX5
Gene	Irag1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 899)
MGRSLTCPFGISPACGAQASWSIFGVGTAEVPGTHSHSNQAAAMPHIPEDEEPPGEPQAAQTQDSPSAGPFPSPPTIVLTGDASSPEGETDKNLVNRAPSPHRRLSHRHLKVSTASLTSVDPSGHVIDLV NDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSLGDSPSAVSPNLSSGASPASSRSCSLTISTSPGLDICSGPQSPLPGAPPQQKGHEDGVSSPCPGEPNVSKGLADLKQNDQRKVSQGRL APRSPTVEKTKELTVEQKENFDPLQHVEATPMAQASGASISGKMALNSPQPGPAEMELGRQLLKTAREGNPLPRTTAQGSGGTVSPHSLGQGSAGEPMGPKAGSKAELRSPVSRPPLIRGVSWDSSPEEP GPLLQKVLAKLPLAEEEKRFPGKAKPAKPPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVE NVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSANIWYHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQN SSRSCGPSEDGVPRTARSMSLTMGKNMPRRRVSVAVVPKFNALNLPGQAPSSSPMPSLPALSESSNGKSSISVSPALPALLENGKTNAEANCEVGAPVPLPSCLEETSQETKAKAEEEAYSKGYQEGVKK TEELQDLKEEEEEEQKTESPEEPEEVEETQEDEKDQGSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLSVVLGLYSSYNSCTEEADGPPGRSTCSAAQRDSWWSSGLQQELPAEQ

Subcellular Location

Description
Membrane {Curator Inference}; Single-pass membrane protein {Curator Inference}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:15388327}. Sarcoplasmic reticulum {ECO:0000269\|PubMed:15388327}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471) Sarcoplasmic Reticulum (GO:0016529)

Biology & Function

Description
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {Experimental EvidencePubMed:10321731, Experimental EvidencePubMed:15388327, Experimental EvidencePubMed:15483626, Experimental EvidencePubMed:16990611}.
Assigned Ontology terms

Biological Process	CGMP-Mediated Signaling (GO:0019934) Negative Regulation Of Smooth Muscle Contraction (GO:0045986) Relaxation Of Vascular Associated Smooth Muscle (GO:0060087)
Molecular Function

Cross-References

Database	Links
UNIPROT	Q9WUX5 Q3U069 Q9R2C5
Pfam	PF05781

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